WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 564288


Description: ZWM026 is a multi-target inhibitor, and an indolocarbazoles analogue derived from mangrove in coastal marine wetland. ZWM026 exhibits selectivity and reversibility against T790M mutant over wild-type EGFR in naturally occurring NSCLC cells and constructed NIH-3T3 cells.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 564288
Name: ZWM026
Chemical Formula: C23H17N3O3
Exact Mass: 383.127
Molecular Weight: 383.41
Elemental Analysis: C, 72.05; H, 4.47; N, 10.96; O, 12.52

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: ZWM-026; ZWM 026; ZWM026

IUPAC/Chemical Name: 12-Ethyl-6-(hydroxymethyl)-12,13-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione


InChi Code: InChI=1S/C23H17N3O3/c1-2-25-15-10-6-4-8-13(15)17-19-18(22(28)26(11-27)23(19)29)16-12-7-3-5-9-14(12)24-20(16)21(17)25/h3-10,24,27H,2,11H2,1H3

SMILES Code: O=C1N(CO)C(C2=C1C3=C(C4=C2C5=C(N4CC)C=CC=C5)NC6=C3C=CC=C6)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

Preparing Stock Solutions

The following data is based on the product molecular weight 383.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Song X, Qi X, Wang Q, Zhu W, Li J. A novel multi-target inhibitor harboring selectivity of inhibiting EGFR T790M sparing wild-type EGFR. Am J Cancer Res. 2017 Sep 1;7(9):1884-1898. eCollection 2017. PubMed PMID: 28979811; PubMed Central PMCID: PMC5622223.