WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 564288
CAS#: NONE
Description: ZWM026 is a multi-target inhibitor, and an indolocarbazoles analogue derived from mangrove in coastal marine wetland. ZWM026 exhibits selectivity and reversibility against T790M mutant over wild-type EGFR in naturally occurring NSCLC cells and constructed NIH-3T3 cells.
MedKoo Cat#: 564288
Name: ZWM026
CAS#: NONE
Chemical Formula: C23H17N3O3
Exact Mass: 383.127
Molecular Weight: 383.41
Elemental Analysis: C, 72.05; H, 4.47; N, 10.96; O, 12.52
This product is not in stock, which may be available by custom synthesis.
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Synonym: ZWM-026; ZWM 026; ZWM026
IUPAC/Chemical Name: 12-Ethyl-6-(hydroxymethyl)-12,13-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione
InChi Key: ZYYKZAMVYVBWFE-UHFFFAOYSA-N
InChi Code: InChI=1S/C23H17N3O3/c1-2-25-15-10-6-4-8-13(15)17-19-18(22(28)26(11-27)23(19)29)16-12-7-3-5-9-14(12)24-20(16)21(17)25/h3-10,24,27H,2,11H2,1H3
SMILES Code: O=C1N(CO)C(C2=C1C3=C(C4=C2C5=C(N4CC)C=CC=C5)NC6=C3C=CC=C6)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
The following data is based on the product molecular weight 383.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Song X, Qi X, Wang Q, Zhu W, Li J. A novel multi-target inhibitor harboring selectivity of inhibiting EGFR T790M sparing wild-type EGFR. Am J Cancer Res. 2017 Sep 1;7(9):1884-1898. eCollection 2017. PubMed PMID: 28979811; PubMed Central PMCID: PMC5622223.
