WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 592513
CAS#: 112892-51-0 (HBr)
Description: Alentemol, also known as U-66444B abd alentamol, is a selective dopamine autoreceptor agonist described as an antipsychotic. Chromosomal breakage following treatment of CHO-K1 cells in vitro with U-68,553B is due to induction of undercondensation of heterochromatin.
MedKoo Cat#: 592513
Name: Alentemol HBr
CAS#: 112892-51-0 (HBr)
Chemical Formula: C19H26BrNO
Exact Mass:
Molecular Weight: 364.33
Elemental Analysis: C, 62.64; H, 7.19; Br, 21.93; N, 3.84; O, 4.39
Related CAS #: 112892-81-6 (HCl) 112891-97-1 (free base) 112892-51-0 (HBr)
Synonym: Alentemol HBr; Alentemol hydrobromide; Alentemol, alentamol, U-66444B; U 66444B; U66444B;
IUPAC/Chemical Name: 2-(dipropylamino)-2,3-dihydro-1H-phenalen-5-ol hydrobromide
InChi Key: FWRWEZVGVJKNMU-UHFFFAOYSA-N
InChi Code: InChI=1S/C19H25NO.BrH/c1-3-8-20(9-4-2)17-10-14-6-5-7-15-12-18(21)13-16(11-17)19(14)15;/h5-7,12-13,17,21H,3-4,8-11H2,1-2H3;1H
SMILES Code: OC1=CC2=C3C(CC(N(CCC)CCC)C2)=CC=CC3=C1.[H]Br
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
| Biological target: | Alentemol, also known as U-66444B, is a selective dopamine autoreceptor agonist. |
| In vitro activity: | TBD |
| In vivo activity: | U-66444B was evaluated for pre- and postsynaptic effects in dopaminergic (DA) cell body and nerve terminal regions of chloral hydrate anesthetized rats. U-66444B depressed DA neurons in substantia nigra pars compacta and ventral tegmental area with a potency three times that for apomorphine. With a sufficient dose, cells were completely silenced. Reference: J Pharmacol Exp Ther. 1990 Aug;254(2):369-74. https://pubmed.ncbi.nlm.nih.gov/1974631/ |
The following data is based on the product molecular weight 364.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | Piercey MF, Broderick PA, Hoffmann WE, Vogelsang GD. U-66444B and U-68553B, potent autoreceptor agonists at dopaminergic cell bodies and terminals. J Pharmacol Exp Ther. 1990 Aug;254(2):369-74. PMID: 1974631. |
| In vitro protocol: | TBD |
| In vivo protocol: | Piercey MF, Broderick PA, Hoffmann WE, Vogelsang GD. U-66444B and U-68553B, potent autoreceptor agonists at dopaminergic cell bodies and terminals. J Pharmacol Exp Ther. 1990 Aug;254(2):369-74. PMID: 1974631. |
1: Yu RL, Aaron CS, Ulrich RG, Thilagar A, Kumaroo PV, Wang Y. Chromosomal breakage following treatment of CHO-K1 cells in vitro with U-68,553B is due to induction of undercondensation of heterochromatin. Environ Mol Mutagen. 1992;20(3):172-87. doi: 10.1002/em.2850200306. PMID: 1396608.
2: Althaus JS, Decker DE, Von Voigtlander PF, Buxser SE. Effects of dopamine agonists on dopamine secretion from PC12 cells: lack of functional autoreceptor activity. Res Commun Chem Pathol Pharmacol. 1991 May;72(2):131-42. PMID: 1678897.
3: Schwende FJ, Rykert UM. Determination of alentamol hydrobromide, a novel antipsychotic agent, in human blood plasma and urine by high-performance liquid chromatography with fluorescence detection and solid-phase extraction. J Chromatogr. 1991 Apr 19;565(1-2):488-96. doi: 10.1016/0378-4347(91)80415-9. PMID: 1874898.
4: Piercey MF, Broderick PA, Hoffmann WE, Vogelsang GD. U-66444B and U-68553B, potent autoreceptor agonists at dopaminergic cell bodies and terminals. J Pharmacol Exp Ther. 1990 Aug;254(2):369-74. PMID: 1974631.
