WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 564205
CAS#: 856436-16-3
Description: JAK3 Inhibitor VI is a cell-permeable, potent, and reversible inhibitor of Janus kinase 3 (JAK3).
MedKoo Cat#: 564205
Name: JAK3 Inhibitor VI
CAS#: 856436-16-3
Chemical Formula: C19H17N3O4S
Exact Mass: 383.094
Molecular Weight: 383.42
Elemental Analysis: C, 59.52; H, 4.47; N, 10.96; O, 16.69; S, 8.36
JAK3 Inhibitor VI, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.
Synonym: JAK3 Inhibitor VI; JAK-3 Inhibitor VI; JAK 3 Inhibitor VI
IUPAC/Chemical Name: (Z)-3-((1H-Pyrrol-2-yl)methylene)-5-(pyridin-3-yl)indolin-2-one Mesylate
InChi Key: ZUDPNBZMAJGYTE-HYMQDMCPSA-N
InChi Code: InChI=1S/C18H13N3O.CH4O3S/c22-18-16(10-14-4-2-8-20-14)15-9-12(5-6-17(15)21-18)13-3-1-7-19-11-13;1-5(2,3)4/h1-11,20H,(H,21,22);1H3,(H,2,3,4)/b16-10-;
SMILES Code: O=C1NC2=C(C=C(C3=CC=CN=C3)C=C2)/C1=C/C4=CC=CN4.OS(=O)(C)=O
The following data is based on the product molecular weight 383.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Nishiya N, Sakamoto Y, Oku Y, Nonaka T, Uehara Y. JAK3 inhibitor VI is a mutant specific inhibitor for epidermal growth factor receptor with the gatekeeper mutation T790M. World J Biol Chem. 2015 Nov 26;6(4):409-18. doi: 10.4331/wjbc.v6.i4.409. PubMed PMID: 26629323; PubMed Central PMCID: PMC4657120.