WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 564205
CAS#: 856436-16-3
Description: JAK3 Inhibitor VI is a cell-permeable, potent, and reversible inhibitor of Janus kinase 3 (JAK3).
MedKoo Cat#: 564205
Name: JAK3 Inhibitor VI
CAS#: 856436-16-3
Chemical Formula: C19H17N3O4S
Exact Mass: 383.094
Molecular Weight: 383.42
Elemental Analysis: C, 59.52; H, 4.47; N, 10.96; O, 16.69; S, 8.36
Synonym: JAK3 Inhibitor VI; JAK-3 Inhibitor VI; JAK 3 Inhibitor VI
IUPAC/Chemical Name: (Z)-3-((1H-Pyrrol-2-yl)methylene)-5-(pyridin-3-yl)indolin-2-one Mesylate
InChi Key: ZUDPNBZMAJGYTE-HYMQDMCPSA-N
InChi Code: InChI=1S/C18H13N3O.CH4O3S/c22-18-16(10-14-4-2-8-20-14)15-9-12(5-6-17(15)21-18)13-3-1-7-19-11-13;1-5(2,3)4/h1-11,20H,(H,21,22);1H3,(H,2,3,4)/b16-10-;
SMILES Code: O=C1NC2=C(C=C(C3=CC=CN=C3)C=C2)/C1=C/C4=CC=CN4.OS(=O)(C)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
The following data is based on the product molecular weight 383.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Nishiya N, Sakamoto Y, Oku Y, Nonaka T, Uehara Y. JAK3 inhibitor VI is a mutant specific inhibitor for epidermal growth factor receptor with the gatekeeper mutation T790M. World J Biol Chem. 2015 Nov 26;6(4):409-18. doi: 10.4331/wjbc.v6.i4.409. PubMed PMID: 26629323; PubMed Central PMCID: PMC4657120.
