VU6001376

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MedKoo CAT#: 555331

CAS#: 1968546-34-0

Description: VU6001376 is a potent and selective mGlu4 PAMs. It has EC50 = 50.1 nM, 50.5% GluMax). It showed selective mGlu4 PAM with an excellent rat DMPK profile (in vivo rat CLp = 3.1 mL/min/kg, t1/2 = 445 min, CYP1A2 IC50 > 30 μM). VU6001376 was also active in reversing haloperidol induced catalepsy in a rodent preclinical model of Parkinson’s disease.


Price and Availability

Size Price Shipping out time Quantity
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Pricing updated 2020-10-29. Prices are subject to change without notice.

VU6001376 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 555331
Name: VU6001376
CAS#: 1968546-34-0
Chemical Formula: C18H14F2N6OS
Exact Mass: 400.0918
Molecular Weight: 400.4078
Elemental Analysis: C, 53.99; H, 3.52; F, 9.49; N, 20.99; O, 4.00; S, 8.01


Synonym: VU6001376; VU-6001376; VU 6001376;

IUPAC/Chemical Name: 6-((1H-pyrazolo[4,3-b]pyridin-3-yl)amino)-N-(3,3-difluorocyclobutyl)benzo[d]isothiazole-3-carboxamide

InChi Key: NWYHEWQGANWLFU-UHFFFAOYSA-N

InChi Code: InChI=1S/C18H14F2N6OS/c19-18(20)7-10(8-18)23-17(27)14-11-4-3-9(6-13(11)28-26-14)22-16-15-12(24-25-16)2-1-5-21-15/h1-6,10H,7-8H2,(H,23,27)(H2,22,24,25)

SMILES Code: O=C(C1=NSC2=CC(NC3=NNC4=CC=CN=C43)=CC=C12)NC5CC(F)(F)C5


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.03.00


References

Discovery, Structure–Activity Relationship, and Biological Characterization of a Novel Series of 6-((1H-Pyrazolo[4,3-b]pyridin-3-yl)amino)-benzo[d]isothiazole-3-carboxamides as Positive Allosteric Modulators of the Metabotropic Glutamate Receptor 4 (mGlu4)
Sean R. Bollinger, Darren W. Engers, Joseph D. Panarese, Mary West, Julie L. Engers, Matthew T. Loch, Alice L. Rodriguez, Anna L. Blobaum, Carrie K. Jones, Analisa Thompson Gray, P. Jeffrey Conn, Craig W. Lindsley, Colleen M. Niswender, and Corey R. Hopkins
Publication Date (Web): September 24, 2018 (Article)
DOI: 10.1021/acs.jmedchem.8b00994