Vedaprofen
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 341611

CAS#: 71109-09-6

Description: Vedaprofen is a nonsteroidal anti-inflammatory drug (NSAID) used in veterinary medicine for the treatment of pain and inflammation due to musculoskeletal disorders in dogs and horses and for the treatment of pain due to horse colic


Chemical Structure

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Vedaprofen
CAS# 71109-09-6

Theoretical Analysis

MedKoo Cat#: 341611
Name: Vedaprofen
CAS#: 71109-09-6
Chemical Formula: C19H22O2
Exact Mass: 282.162
Molecular Weight: 282.383
Elemental Analysis: C, 80.82; H, 7.85; O, 11.33

Price and Availability

Size Price Availability Quantity
5.0mg USD 275.0 2 Weeks
10.0mg USD 395.0 2 Weeks
25.0mg USD 725.0 2 Weeks
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Synonym: Vedaprofen; PM 150; PM-150; PM150.

IUPAC/Chemical Name: 4-Cyclohexyl-alpha-methylnaphthalene-1-acetic acid

InChi Key: VZUGVMQFWFVFBX-UHFFFAOYSA-N

InChi Code: InChI=1S/C19H22O2/c1-13(19(20)21)15-11-12-16(14-7-3-2-4-8-14)18-10-6-5-9-17(15)18/h5-6,9-14H,2-4,7-8H2,1H3,(H,20,21)

SMILES Code: O=C(O)C(C)C1=C2C=CC=CC2=C(C3CCCCC3)C=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

Preparing Stock Solutions

The following data is based on the product molecular weight 282.383 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Fantoni DT, Ida KK, de Almeida TI, Ambrósio AM. A comparison of pre and post-operative vedaprofen with ketoprofen for pain control in dogs. BMC Vet Res. 2015 Feb 7;11:24. doi: 10.1186/s12917-015-0338-4. PubMed PMID: 25880775; PubMed Central PMCID: PMC4324799.

2: Yin Z, Wang Y, Whittell LR, Jergic S, Liu M, Harry E, Dixon NE, Kelso MJ, Beck JL, Oakley AJ. DNA replication is the target for the antibacterial effects of nonsteroidal anti-inflammatory drugs. Chem Biol. 2014 Apr 24;21(4):481-487. doi: 10.1016/j.chembiol.2014.02.009. Epub 2014 Mar 13. PubMed PMID: 24631121.

3: Vilés K, Rabanal R, Rodríguez-Prado M, Miró J. Effect of ketoprofen treatment on the uterine inflammatory response after AI of jennies with frozen semen. Theriogenology. 2013 Apr 15;79(7):1019-26. doi: 10.1016/j.theriogenology.2013.01.006. Epub 2013 Feb 28. PubMed PMID: 23453786.

4: Ishihara M, Fujita K, Ito H, Matsuda T, Yatsukawa Y, Nakamura M, Sakai T, Nemoto S. [Determination of vedaprofen in livestock products and seafoods by liquid chromatography-tandem mass spectrometry]. Shokuhin Eiseigaku Zasshi. 2011;52(5):304-8. Japanese. PubMed PMID: 22200750.

5: Dubreil-Chéneau E, Pirotais Y, Bessiral M, Roudaut B, Verdon E. Development and validation of a confirmatory method for the determination of 12 non steroidal anti-inflammatory drugs in milk using liquid chromatography-tandem mass spectrometry. J Chromatogr A. 2011 Sep 16;1218(37):6292-301. doi: 10.1016/j.chroma.2011.06.006. Epub 2011 Jun 12. PubMed PMID: 21840010.

6: Khwanjai V, Chuthatep S, Durongphongtorn S, Yibchok-Anun S. Evaluating the effects of 14-day oral vedaprofen and tolfenamic acid treatment on renal function, hematological and biochemical profiles in healthy cats. J Vet Pharmacol Ther. 2012 Feb;35(1):13-8. doi: 10.1111/j.1365-2885.2011.01282.x. Epub 2011 Mar 11. PubMed PMID: 21392038.

7: Brondani JT, Luna SP, Padovani CR. Refinement and initial validation of a multidimensional composite scale for use in assessing acute postoperative pain in cats. Am J Vet Res. 2011 Feb;72(2):174-83. doi: 10.2460/ajvr.72.2.174. PubMed PMID: 21281191.

8: Gallo P, Fabbrocino S, Dowling G, Salini M, Fiori M, Perretta G, Serpe L. Confirmatory analysis of non-steroidal anti-inflammatory drugs in bovine milk by high-performance liquid chromatography with fluorescence detection. J Chromatogr A. 2010 Apr 23;1217(17):2832-9. doi: 10.1016/j.chroma.2010.02.047. Epub 2010 Feb 25. PubMed PMID: 20227702.

9: Rojer H, Aurich C. Treatment of persistent mating-induced endometritis in mares with the non-steroid anti-inflammatory drug vedaprofen. Reprod Domest Anim. 2010 Dec;45(6):e458-60. doi: 10.1111/j.1439-0531.2009.01572.x. PubMed PMID: 20074320.

10: Koblischke P, Budik S, Müller J, Aurich C. Practical experience with the treatment of recipient mares with a non-steroidal anti-inflammatory drug in an equine embryo transfer programme. Reprod Domest Anim. 2010 Dec;45(6):1039-41. doi: 10.1111/j.1439-0531.2009.01486.x. PubMed PMID: 19515030.

11: Brondani JT, Loureiro Luna SP, Beier SL, Minto BW, Padovani CR. Analgesic efficacy of perioperative use of vedaprofen, tramadol or their combination in cats undergoing ovariohysterectomy. J Feline Med Surg. 2009 Jun;11(6):420-9. doi: 10.1016/j.jfms.2008.10.002. Epub 2009 Feb 23. PubMed PMID: 19233698.

12: Brondani JT, Luna SP, Marcello GC, Padovani CR. Perioperative administration of vedaprofen, tramadol or their combination does not interfere with platelet aggregation, bleeding time and biochemical variables in cats. J Feline Med Surg. 2009 Jun;11(6):503-9. doi: 10.1016/j.jfms.2008.12.003. Epub 2009 Jan 24. PubMed PMID: 19168382.

13: Hazewinkel HA, van den Brom WE, Theyse LF, Pollmeier M, Hanson PD. Comparison of the effects of firocoxib, carprofen and vedaprofen in a sodium urate crystal induced synovitis model of arthritis in dogs. Res Vet Sci. 2008 Feb;84(1):74-9. Epub 2007 Apr 3. PubMed PMID: 17408711.

14: Lopez S, Pertuy S, Horspool L, van Laar P, Rutten A. Vedaprofen therapy in cats with upper respiratory tract infection or following ovariohysterectomy. J Small Anim Pract. 2007 Feb;48(2):70-5. PubMed PMID: 17286658.

15: Popot MA, Donval A, Bonnaire Y, Huau J. Use of accelerating solvent extraction for detecting non-steroidal anti-inflammatory drugs in horse feces. J Anal Toxicol. 2006 Jun;30(5):323-30. PubMed PMID: 16839470.

16: Janett F, Aebi L, Burger D, Imboden I, Hässig M, Kindahl H, Thun R. Influence of vedaprofen (Quadrisol) on quality and freezability of stallion semen. Theriogenology. 2005 Nov;64(8):1867-77. Epub 2005 Jun 13. PubMed PMID: 15955550.

17: Hoeijmakers M, Coert A, Helden H, Horspool LJ. The pharmacokinetics of vedaprofen and its enantiomers in dogs after single and multiple dosing. J Vet Pharmacol Ther. 2005 Jun;28(3):305-12. PubMed PMID: 15953205.

18: Soraci AL, Tapia O, Garcia J. Pharmacokinetics and synovial fluid concentrations of flurbiprofen enantiomers in horses: chiral inversion. J Vet Pharmacol Ther. 2005 Feb;28(1):65-70. PubMed PMID: 15720517.

19: Lees P, Giraudel J, Landoni MF, Toutain PL. PK-PD integration and PK-PD modelling of nonsteroidal anti-inflammatory drugs: principles and applications in veterinary pharmacology. J Vet Pharmacol Ther. 2004 Dec;27(6):491-502. Review. PubMed PMID: 15601443.

20: Robertson SA, Taylor PM. Pain management in cats--past, present and future. Part 2. Treatment of pain--clinical pharmacology. J Feline Med Surg. 2004 Oct;6(5):321-33. Review. PubMed PMID: 15363764.