Vapiprost hydrochloride
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MedKoo CAT#: 341399

CAS#: 87248-13-3

Description: Vapiprost hydrochloride is a biochemical..


Chemical Structure

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Vapiprost hydrochloride
CAS# 87248-13-3

Theoretical Analysis

MedKoo Cat#: 341399
Name: Vapiprost hydrochloride
CAS#: 87248-13-3
Chemical Formula: C30H40ClNO4
Exact Mass: 513.26
Molecular Weight: 514.103
Elemental Analysis: C, 70.09; H, 7.84; Cl, 6.90; N, 2.72; O, 12.45

Price and Availability

Size Price Availability Quantity
1mg USD 370 2 Weeks
5mg USD 1050 2 Weeks
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Synonym: Vapiprost hydrochloride; GR 32191B; GR-32191B; GR32191B; Vapiprost HCl;

IUPAC/Chemical Name: 4-Heptenoic acid, 7-(5-((1,1'-biphenyl)-4-ylmethoxy)-3-hydroxy-2-(1-piperidinyl)cyclopentyl)-, hydrochloride, (1R-(1alpha(Z),2beta,3beta,5alpha))-

InChi Key: ZYOBZRTZRQKKNC-UGNABIHOSA-N

InChi Code: InChI=1S/C30H39NO4.ClH/c32-27-21-28(35-22-23-15-17-25(18-16-23)24-11-5-3-6-12-24)26(13-7-1-2-8-14-29(33)34)30(27)31-19-9-4-10-20-31;/h1-3,5-6,11-12,15-18,26-28,30,32H,4,7-10,13-14,19-22H2,(H,33,34);1H/b2-1-;/t26-,27-,28-,30+;/m0./s1

SMILES Code: O=C(O)CC/C=C\CC[C@@H]1[C@@H](N2CCCCC2)[C@@H](O)C[C@@H]1OCC3=CC=C(C4=CC=CC=C4)C=C3.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 514.10 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Cracowski JL, Stanke-Labesque F, Devillier P, Chavanon O, Hunt M, Souvignet C, Bessard G. Human internal mammary artery contraction by isoprostaglandin f(2alpha) type-III [8-iso-prostaglandin F(2alpha)]. Eur J Pharmacol. 2000 May 26;397(1):161-8. PubMed PMID: 10844110.

2: Barchasz E, Naline E, Molimard M, Moreau J, Georges O, Emonds-Alt X, Advenier C. Interleukin-1beta-induced hyperresponsiveness to [Sar9,Met(O2)11]substance P in isolated human bronchi. Eur J Pharmacol. 1999 Aug 20;379(1):87-95. PubMed PMID: 10499376.

3: Horie S, Yamada M, Satoh M, Noritake S, Hiraishi S, Kizaki K, Kurusu O, Nakahara T, Ishii H, Kazama M. The potent inhibition of vapiprost, a novel thromboxane A2 receptor antagonist, on the secondary aggregation and ATP release of human platelets. Biol Pharm Bull. 1997 Jun;20(6):625-31. PubMed PMID: 9212979.

4: Molimard M, Martin CA, Naline E, Hirsch A, Advenier C. Role of thromboxane A2 in bradykinin-induced human isolated small bronchi contraction. Eur J Pharmacol. 1995 May 4;278(1):49-54. PubMed PMID: 7545124.

5: Ogletree ML, Allen GT. Interspecies differences in thromboxane receptors: studies with thromboxane receptor antagonists in rat and guinea pig smooth muscles. J Pharmacol Exp Ther. 1992 Feb;260(2):789-94. PubMed PMID: 1531361.

6: Takahara K, Murray R, FitzGerald GA, Fitzgerald DJ. The response to thromboxane A2 analogues in human platelets. Discrimination of two binding sites linked to distinct effector systems. J Biol Chem. 1990 Apr 25;265(12):6836-44. PubMed PMID: 2139029.