SLN 52449
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MedKoo CAT#: 573030

CAS#: 153252-44-9

Description: SLN 52449, also known as Azido-PEG4-tetra-Ac-beta-D-glucose is a PEG derivative containing one azide group and one D-glucose group. The azide group enables Click Chemistry. The hydrophilic PEG spacer increases solubility in aqueous media. D-glucose increases solubility in aqueous media and increases the selectivity of the PEGylation reaction. This product has no formal name at the moment. For the convenience of communication, a temporary code name was therefore proposed according to MedKoo Chemical Nomenclature (see web page: https://www.medkoo.com/page/naming).

Chemical Structure

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SLN 52449
CAS# 153252-44-9
Product data Instruction

Theoretical Analysis

MedKoo Cat#: 573030
Name: SLN 52449
CAS#: 153252-44-9
Chemical Formula: C22H35N3O13
Exact Mass: 549.22
Molecular Weight: 549.530
Elemental Analysis: C, 48.09; H, 6.42; N, 7.65; O, 37.85

Price and Availability

Size Price Availability Quantity
50mg USD 530 2 weeks
100mg USD 900 2 weeks
250mg USD 1350 2 weeks
1g USD 3200 2 weeks
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Synonym: Azido-PEG4-tetra-Ac-beta-D-glucose; SLN52449; SLN 52449; SLN-52449

IUPAC/Chemical Name: (2R,3R,4S,5R,6R)-2-(acetoxymethyl)-6-(2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethoxy)tetrahydro-2H-pyran-3,4,5-triyl triacetate

InChi Key: SBLCSGRZSLBMCF-LJUXMERYSA-N

InChi Code: InChI=1S/C22H35N3O13/c1-14(26)34-13-18-19(35-15(2)27)20(36-16(3)28)21(37-17(4)29)22(38-18)33-12-11-32-10-9-31-8-7-30-6-5-24-25-23/h18-22H,5-13H2,1-4H3/t18-,19?,20?,21?,22-/m1/s1

SMILES Code: O=C(O[C@H]1[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@H](OCCOCCOCCOCCN=[N+]=[N-])O[C@@H]1COC(C)=O)C

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Product Data:
Product Data
Instruction:
View handling instruction
Biological target: SLN 52449 enables selective attachment of molecules to specific targets in the body.
In vitro activity: To be determined
In vivo activity: To be determined

Preparing Stock Solutions

The following data is based on the product molecular weight 549.53 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol: To be determined
In vitro protocol: To be determined
In vivo protocol: To be determined

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1: Sano K, Nakajima T, Miyazaki K, Ohuchi Y, Ikegami T, Choyke PL, Kobayashi H. Short PEG-linkers improve the performance of targeted, activatable monoclonal antibody-indocyanine green optical imaging probes. Bioconjug Chem. 2013 May 15;24(5):811-6. doi: 10.1021/bc400050k. Epub 2013 May 3. PubMed PMID: 23600922; PubMed Central PMCID: PMC3674550.

2: Harrison E, Coulter JA, Dixon D. Gold nanoparticle surface functionalization: mixed monolayer versus hetero bifunctional peg linker. Nanomedicine (Lond). 2016 Apr;11(7):851-65. Review. PubMed PMID: 27021417.

3: Augusto MT, Hollmann A, Porotto M, Moscona A, Santos NC. Antiviral Lipopeptide-Cell Membrane Interaction Is Influenced by PEG Linker Length. Molecules. 2017 Jul 15;22(7). pii: E1190. doi: 10.3390/molecules22071190. PubMed PMID: 28714870; PubMed Central PMCID: PMC5776016.

4: Tuma R, Russell M, Rosendahl M, Thomas GJ Jr. Solution conformation of the extracellular domain of the human tumor necrosis factor receptor probed by Raman and UV-resonance Raman spectroscopy: structural effects of an engineered PEG linker. Biochemistry. 1995 Nov 21;34(46):15150-6. PubMed PMID: 7578129.

5: Kanazaki K, Sano K, Makino A, Yamauchi F, Takahashi A, Homma T, Ono M, Saji H. Feasibility of poly(ethylene glycol) derivatives as diagnostic drug carriers for tumor imaging. J Control Release. 2016 Mar 28;226:115-23. doi:10.1016/j.jconrel.2016.02.017. Epub 2016 Feb 8. PubMed PMID: 26869546.