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MedKoo CAT#: 581417

CAS#: 57-44-3

Description: Barbital is discontinued, DEA controlled substance. It is a long-acting barbiturate that depresses most metabolic processes at high doses. It is used as a hypnotic and sedative and may induce dependence. Barbital is also used in veterinary practice for central nervous system depression.

Price and Availability

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Pricing updated 2020-10-26. Prices are subject to change without notice.

Barbital is discontinued, DEA controlled substance.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 581417
Name: Barbital
CAS#: 57-44-3
Chemical Formula: C8H12N2O3
Exact Mass: 184.0848
Molecular Weight: 184.195
Elemental Analysis: C, 52.17; H, 6.57; N, 15.21; O, 26.06

Synonym: Barbital; Barbitone; Dormonal; Veroletten; Vesperal; Malonal

IUPAC/Chemical Name: 2,4,6(1H,3H,5H)-Pyrimidinetrione, 5,5-diethyl-


InChi Code: InChI=1S/C8H12N2O3/c1-3-8(4-2)5(11)9-7(13)10-6(8)12/h3-4H2,1-2H3,(H2,9,10,11,12,13)


Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:


1: Gryl M, Seidler T, Wojnarska J, Stadnicka K, Matulková I, Němec I, Němec P. Co-Crystals of 2-Amino-5-Nitropyridine Barbital with Extreme Birefringence and Large Second Harmonic Generation Effect. Chemistry. 2018 Jun 21;24(35):8727-8731. doi: 10.1002/chem.201802057. Epub 2018 Jun 7. PubMed PMID: 29733105.

2: Kütahya C, Schmitz C, Strehmel V, Yagci Y, Strehmel B. Near-Infrared Sensitized Photoinduced Atom-Transfer Radical Polymerization (ATRP) with a Copper(II) Catalyst Concentration in the ppm Range. Angew Chem Int Ed Engl. 2018 Jun 25;57(26):7898-7902. doi: 10.1002/anie.201802964. Epub 2018 May 16. PubMed PMID: 29637671.

3: Deng L, Shi AM, Wang Q. Sedative-hypnotic and anxiolytic effects and the mechanism of action of aqueous extracts of peanut stems and leaves in mice. J Sci Food Agric. 2018 Oct;98(13):4885-4894. doi: 10.1002/jsfa.9020. Epub 2018 May 17. PubMed PMID: 29572847.

4: Du JJ, Hanrahan JR, Solomon VR, Williams PA, Groundwater PW, Overgaard J, Platts JA, Hibbs DE. Exploring the Binding of Barbital to a Synthetic Macrocyclic Receptor. A Charge Density Study. J Phys Chem A. 2018 Mar 22;122(11):3031-3044. doi: 10.1021/acs.jpca.7b11674. Epub 2018 Mar 13. PubMed PMID: 29481082.

5: Ruspini SF, Zuccoli JR, Lavandera JV, Martínez MDC, Oliveri LM, Gerez EN, Batlle AMDC, Buzaleh AM. Effects of volatile anaesthetics on heme metabolism in a murine genetic model of Acute Intermittent Porphyria. A comparative study with other porphyrinogenic drugs. Biochim Biophys Acta Gen Subj. 2018 Jun;1862(6):1296-1305. doi: 10.1016/j.bbagen.2018.02.013. Epub 2018 Feb 22. PubMed PMID: 29476795.

6: Zhang L, Wu P, Jin Q, Hu Z, Wang J. Multi-residue analysis of sedative drugs in human plasma by ultra-high performance liquid chromatography tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Jan 1;1072:305-314. doi: 10.1016/j.jchromb.2017.11.035. Epub 2017 Nov 28. PubMed PMID: 29202362.

7: Lee JH, Park HN, Choi JY, Kim NS, Park HJ, Park SS, Baek SY. Simultaneous analysis by Quadrupole-Orbitrap mass spectrometry and UHPLC-MS/MS for the determination of sedative-hypnotics and sleep inducers in adulterated products. J Sep Sci. 2017 Dec;40(24):4677-4688. doi: 10.1002/jssc.201700879. Epub 2017 Nov 13. PubMed PMID: 29057572.

8: Panayi F, Sors A, Bert L, Martin B, Rollin-Jego G, Billiras R, Carrié I, Albinet K, Danober L, Rogez N, Thomas JY, Pira L, Bertaina-Anglade V, Lestage P. In vivo pharmacological profile of S 38093, a novel histamine H3 receptor inverse agonist. Eur J Pharmacol. 2017 May 15;803:1-10. doi: 10.1016/j.ejphar.2017.03.008. Epub 2017 Mar 14. PubMed PMID: 28315340.

9: Giménez-Roldán S. Cajal's unbearable cephalalgias: The consequences of a misdiagnosis. Rev Neurol (Paris). 2016 Nov;172(11):680-688. doi: 10.1016/j.neurol.2016.09.013. Epub 2016 Oct 28. Review. PubMed PMID: 28029372.

10: Zhang X, Lin Z, Li J, Huang Z, Rao Y, Liang H, Yan J, Zheng F. Rapid determination of nine barbiturates in human whole blood by liquid chromatography-tandem mass spectrometry. Drug Test Anal. 2017 Apr;9(4):588-595. doi: 10.1002/dta.2002. Epub 2016 Jul 1. PubMed PMID: 27368111.

11: Zhang XY, Lü FQ, Tang J. [Effects of ischemic preconditioning on the serum testosterone level and spermatogenic cell apoptosis in rabbits with testicular ischemia-reperfusion]. Zhonghua Nan Ke Xue. 2016 Jul;22(7):596-601. Chinese. PubMed PMID: 28965375.

12: Anilanmert B, Çavuş F, Narin I, Cengiz S, Sertler Ş, Özdemir AA, Açikkol M. Simultaneous analysis method for GHB, ketamine, norketamine, phenobarbital, thiopental, zolpidem, zopiclone and phenytoin in urine, using C18 poroshell column. J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Jun 1;1022:230-241. doi: 10.1016/j.jchromb.2016.03.040. Epub 2016 Apr 9. PubMed PMID: 27107852.

13: Jebabli N, Gaïes E, El Jebari H, Charfi R, Lakhal M, Klouz A, Trabelsi S, Salouage I. [Development and validation of a new HPLC method for determination of Lamotrigine and clinical application]. Tunis Med. 2015 Aug-Sep;93(8-9):565-8. French. PubMed PMID: 26815525.

14: Liu JB, Wang Y, Su TT, Li B, Tang SS, Jin RF. Theoretical and experimental studies on the performances of barbital-imprinted systems. J Sep Sci. 2015 Dec;38(23):4105-10. doi: 10.1002/jssc.201500891. Epub 2015 Nov 3. PubMed PMID: 26420630.

15: Zhao W, Li Y, Ma W, Ge Y, Huang Y. A study on quality components and sleep-promoting effects of GABA black tea. Food Funct. 2015 Oct;6(10):3393-8. doi: 10.1039/c5fo00265f. PubMed PMID: 26290415.

16: Fujinuma K, Ishii Y, Yashihashi Y, Yonemochi E, Sugano K, Tarada K. Triboelectrification of active pharmaceutical ingredients: week acids and their salts. Int J Pharm. 2015 Sep 30;493(1-2):434-8. doi: 10.1016/j.ijpharm.2015.08.008. Epub 2015 Aug 4. PubMed PMID: 26253375.

17: Anani WQ, Ojerholm E, Shurin MR. Resolving Transferrin Isoforms via Agarose Gel Electrophoresis. Lab Med. 2015 Winter;46(1):26-33. doi: 10.1309/LMVS2JB8JZN8MDVM. PubMed PMID: 25617389.

18: Norn S, Permin H, Kruse E, Kruse PR. [On the history of barbiturates]. Dan Medicinhist Arbog. 2015;43:133-51. Danish. PubMed PMID: 27086450.

19: McGrath JM, Pluth MD. Linear free energy relationships reveal structural changes in hydrogen-bonded host-guest interactions. J Org Chem. 2014 Dec 5;79(23):11797-801. doi: 10.1021/jo502325w. Epub 2014 Nov 20. PubMed PMID: 25412431; PubMed Central PMCID: PMC4260963.

20: Vastrad BM, Neelagund SE, Iiger SR, Godbole AM, Kulkarni V. Improved Rifamycin B Production by Nocardia mediterranei MTCC 14 under Solid-State Fermentation through Process Optimization. Biochem Res Int. 2014;2014:621309. doi: 10.1155/2014/621309. Epub 2014 Oct 9. PubMed PMID: 25371823; PubMed Central PMCID: PMC4209767.