RG7834 R-isomer
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MedKoo CAT#: 555327

CAS#: 2072057-18-0 (R-isomer)

Description: RG7834 R-isomer is an enantiomer of RG7834. RG7834 R-isomer has R-configuration with CAS#2072057-18-0. RG7834 is a novel oral HBV viral gene expression inhibitor that blocks viral antigen and virion production. RG7834 is highly selective for HBV, and has a unique antiviral profile that is clearly differentiated from nucleos(t)ide analogues.


Price and Availability

Size
Price

10mg
USD 250
100mg
USD 1250
Size
Price

25mg
USD 450
200mg
USD 1950
Size
Price

50mg
USD 750
1g
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RG7834 R-isomer, purity > 98%, is in stock. The same day shipping out after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 555327
Name: RG7834 R-isomer
CAS#: 2072057-18-0 (R-isomer)
Chemical Formula: C22H27NO6
Exact Mass: 401.1838
Molecular Weight: 401.459
Elemental Analysis: C, 65.82; H, 6.78; N, 3.49; O, 23.91


Related CAS #: 199482-36-3 (S-isomer hydrate)   2072057-17-9 (S-isomer)   2072057-18-0 (R-isomer)   1802407-46-0 (racemic)  

Synonym: RG7834 R-isomer; RG 7834 R-isomer; RG-7834 R-isomer; RO7020322 R-isomer; RO 7020322 R-isomer; RO-7020322 R-isomer

IUPAC/Chemical Name: (6R)-6-Isopropyl-10-methoxy-9-(3-methoxypropoxy)-2-oxo-6,7-dihydrobenzo[a]quinolizine-3-carboxylic acid

InChi Key: KBXLMOYQNDMHQT-QGZVFWFLSA-N

InChi Code: InChI=1S/C22H27NO6/c1-13(2)17-8-14-9-21(29-7-5-6-27-3)20(28-4)10-15(14)18-11-19(24)16(22(25)26)12-23(17)18/h9-13,17H,5-8H2,1-4H3,(H,25,26)/t17-/m1/s1

SMILES Code: O=C(C1=CN2[C@@H](C(C)C)CC3=CC(OCCCOC)=C(OC)C=C3C2=CC1=O)O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Certificate of Analysis:

Safety Data Sheet (MSDS):

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
2934990300


References

1: Mueller H, Wildum S, Luangsay S, Walther J, Lopez A, Tropberger P, Ottaviani G, Lu W, Parrott NJ, Zhang JD, Schmucki R, Racek T, Hoflack JC, Kueng E, Point F, Zhou X, Steiner G, Lütgehetmann M, Rapp G, Volz T, Dandri M, Yang S, Young JAT, Javanbakht H. A novel orally available small molecule that inhibits hepatitis B virus expression. J Hepatol. 2018 Mar;68(3):412-420. doi: 10.1016/j.jhep.2017.10.014. Epub 2017 Oct 25. PubMed PMID: 29079285