Varlitinib Tosylate

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 564072

CAS#: 1146629-86-8

Description: Varlitinib Tosylate is a selective and potent ErbB1(EGFR) and ErbB2(HER2) inhibitor.


Price and Availability

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Varlitinib tosylate is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 564072
Name: Varlitinib Tosylate
CAS#: 1146629-86-8
Chemical Formula: C36H35ClN6O8S3
Exact Mass: 810.1367
Molecular Weight: 811.34
Elemental Analysis: C, 53.29; H, 4.35; Cl, 4.37; N, 10.36; O, 15.78; S, 11.85


Synonym: ARRY-334543 Tosylate; ARRY-543 Tosylate; Varlitinib Tosylate; Varlitinib-Tosylate;

IUPAC/Chemical Name: 4-N-[3-Chloro-4-(1,3-thiazol-2-ylmethoxy)phenyl]-6-N-[(4R)-4-methyl-4,5-dihydro-1,3-oxazol-2-yl]quinazoline-4,6-diamine;4-methylbenzenesulfonic acid

InChi Key: QSUPQMGDXOHVLK-FFXKMJQXSA-N

InChi Code: InChI=1S/C22H19ClN6O2S.2C7H8O3S/c1-13-10-31-22(27-13)29-14-2-4-18-16(8-14)21(26-12-25-18)28-15-3-5-19(17(23)9-15)30-11-20-24-6-7-32-20;2*1-6-2-4-7(5-3-6)11(8,9)10/h2-9,12-13H,10-11H2,1H3,(H,27,29)(H,25,26,28);2*2-5H,1H3,(H,8,9,10)/t13-;;/m1../s1

SMILES Code: C[C@H]1N=C(NC2=CC3=C(NC4=CC=C(OCC5=NC=CS5)C(Cl)=C4)N=CN=C3C=C2)OC1.O=S(C6=CC=C(C)C=C6)(O)=O.O=S(C7=CC=C(C)C=C7)(O)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
2934.99.03.00