JI051
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MedKoo CAT#: 564052

CAS#: 2234281-75-3

Description: JI051 is an inhibitor of the cancer-associated transcription factor Hes1 via the PHB2 chaperone. JI051 stabilizes PHB2's interaction with Hes1 outside the nucleus, inducing G2/M cell cycle arrest.


Chemical Structure

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JI051
CAS# 2234281-75-3

Theoretical Analysis

MedKoo Cat#: 564052
Name: JI051
CAS#: 2234281-75-3
Chemical Formula: C22H24N2O3
Exact Mass: 364.1787
Molecular Weight: 364.45
Elemental Analysis: C, 72.51; H, 6.64; N, 7.69; O, 13.17

Price and Availability

Size Price Availability Quantity
50.0mg USD 550.0 2 Weeks
100.0mg USD 950.0 2 Weeks
200.0mg USD 1650.0 2 Weeks
500.0mg USD 2650.0 2 Weeks
1.0g USD 3250.0 2 Weeks
2.0g USD 5850.0 2 Weeks
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Synonym: JI051; JI-051; JI 051

IUPAC/Chemical Name: (E)-N-(2-Ethoxyphenethyl)-3-(7-methoxy-1H-indol-2-yl)acrylamide

InChi Key: XIXIBPRUNJKZQI-VAWYXSNFSA-N

InChi Code: InChI=1S/C22H24N2O3/c1-3-27-19-9-5-4-7-16(19)13-14-23-21(25)12-11-18-15-17-8-6-10-20(26-2)22(17)24-18/h4-12,15,24H,3,13-14H2,1-2H3,(H,23,25)/b12-11+

SMILES Code: O=C(NCCC1=CC=CC=C1OCC)/C=C/C(N2)=CC3=C2C(OC)=CC=C3

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 364.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Perron A, Nishikawa Y, Iwata J, Shimojo H, Takaya J, Kobayashi K, Imayoshi I, Mbenza NM, Takenoya M, Kageyama R, Kodama Y, Uesugi M. Small-molecule screening yields a compound that inhibits the cancer-associated transcription factor Hes1 via the PHB2 chaperone. J Biol Chem. 2018 May 25;293(21):8285-8294. doi: 10.1074/jbc.RA118.002316. Epub 2018 Mar 9. PubMed PMID: 29523683; PubMed Central PMCID: PMC5971435.

JI051

50.0mg / USD 550.0