Panthenol

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MedKoo CAT#: 341386

CAS#: 16485-10-2

Description: Panthenol (also called pantothenol) is the alcohol analog of pantothenic acid (vitamin B5), and is thus a provitamin of B5. In organisms it is quickly oxidized to pantothenic acid. It is a viscous transparent liquid at room temperature. Panthenol is used as a moisturizer and to improve wound healing in pharmaceutical and cosmetic products.


Price and Availability

Size Price Shipping out time Quantity
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Pricing updated 2020-07-10. Prices are subject to change without notice.

Panthenol is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 341386
Name: Panthenol
CAS#: 16485-10-2
Chemical Formula: C9H19NO4
Exact Mass: 205.1314
Molecular Weight: 205.254
Elemental Analysis: C, 52.67; H, 9.33; N, 6.82; O, 31.18


Synonym: Panthenol; Dexpanthenol;

IUPAC/Chemical Name: Butanamide, 2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethyl-

InChi Key: SNPLKNRPJHDVJA-UHFFFAOYSA-N

InChi Code: InChI=1S/C9H19NO4/c1-9(2,6-12)7(13)8(14)10-4-3-5-11/h7,11-13H,3-6H2,1-2H3,(H,10,14)

SMILES Code: O=C(NCCCO)C(O)C(C)(C)CO


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.03.00


References

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2: Duman N, Duman R, Tosun M, Akıcı M, Göksel E, Gökçe B, Alagöz O. Topical folinic acid enhances wound healing in rat model. Adv Med Sci. 2018 Aug 6;63(2):347-352. doi: 10.1016/j.advms.2018.04.011. [Epub ahead of print] PubMed PMID: 30092503.

3: Doganay A, Koksel B, Gundogdu SO, Capan Y. Simultaneous Determination of Dexpanthenol, Lidocaine Hydrochloride, Mepyramine Maleate and their Related Substances by a RP-HPLC Method in Topical Dosage Forms. J Chromatogr Sci. 2018 Jul 31. doi: 10.1093/chromsci/bmy067. [Epub ahead of print] PubMed PMID: 30085004.

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6: Augustin M, Wilsmann-Theis D, Körber A, Kerscher M, Itschert G, Dippel M, Staubach P. Positionspapier: Diagnostik und Therapie der Xerosis cutis. J Dtsch Dermatol Ges. 2018 Jul;16 Suppl 4:3-35. doi: 10.1111/ddg.13580. PubMed PMID: 29989340.

7: Pehlivanlı F, Aydin O, Karaca G, Aydin G, Devrim T, Bulut H, Bakar B, Daphan ÇE. Healing of Ischemic Colon Anastomosis in Rats Could Be Provided by Administering Dexpanthenol or Coenzyme Q10. J Clin Med. 2018 Jun 25;7(7). pii: E161. doi: 10.3390/jcm7070161. PubMed PMID: 29941836; PubMed Central PMCID: PMC6069384.

8: Wang J, Planz V, Vukosavljevic B, Windbergs M. Multifunctional electrospun nanofibers for wound application - Novel insights into the control of drug release and antimicrobial activity. Eur J Pharm Biopharm. 2018 Aug;129:175-183. doi: 10.1016/j.ejpb.2018.05.035. Epub 2018 May 30. PubMed PMID: 29859280.

9: Kalkan F, Parlakpinar H, Disli OM, Tanriverdi LH, Ozhan O, Polat A, Cetin A, Vardi N, Otlu YO, Acet A. Protective and therapeutic effects of dexpanthenol on isoproterenol-induced cardiac damage in rats. J Cell Biochem. 2018 Sep;119(9):7479-7489. doi: 10.1002/jcb.27058. Epub 2018 May 18. PubMed PMID: 29775243.

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11: Pavlačková J, Egner P, Sedláček T, Mokrejš P, Sedlaříková J, Polášková J. In vivo efficacy and properties of semisolid formulations containing panthenol. J Cosmet Dermatol. 2018 Mar 25. doi: 10.1111/jocd.12527. [Epub ahead of print] PubMed PMID: 29577586.

12: Gordon WC, López VG, Bhattacharjee S, Gil DR, Díaz JA, de la Losa FP, Peláez RP, Ferrer CT, Bacchini GS, Jun B, Varoqui H, Bazan NG. A Nonsteroidal Novel Formulation Targeting Inflammatory and Pruritus-Related Mediators Modulates Experimental Allergic Contact Dermatitis. Dermatol Ther (Heidelb). 2018 Mar;8(1):111-126. doi: 10.1007/s13555-018-0223-8. Epub 2018 Feb 16. PubMed PMID: 29453524; PubMed Central PMCID: PMC5825328.

13: Dung TH, Huong LT, Yoo H. Morphological Feature of Pluronic F127 and Its Application in Burn Treatment. J Nanosci Nanotechnol. 2018 Feb 1;18(2):829-832. doi: 10.1166/jnn.2018.14880. PubMed PMID: 29448500.

14: Ali M, Abdel Motaal A, Ahmed MA, Alsayari A, El-Gazayerly ON. An in vivo study of Hypericum perforatum in a niosomal topical drug delivery system. Drug Deliv. 2018 Nov;25(1):417-425. doi: 10.1080/10717544.2018.1431977. PubMed PMID: 29382233; PubMed Central PMCID: PMC6058565.

15: da Gama RM, França-Stefoni SA, Sá-Dias TC, Bedin V, Baby AR, Velasco MVR. Protective effect of conditioner agents on hair treated with oxidative hair dye. J Cosmet Dermatol. 2018 Jan 7. doi: 10.1111/jocd.12484. [Epub ahead of print] PubMed PMID: 29316174.

16: Planz V, Wang J, Windbergs M. Establishment of a cell-based wound healing assay for bio-relevant testing of wound therapeutics. J Pharmacol Toxicol Methods. 2018 Jan - Feb;89:19-25. doi: 10.1016/j.vascn.2017.10.003. Epub 2017 Oct 14. PubMed PMID: 29038019.

17: Martell JD, Porter-Zasada LB, Forse AC, Siegelman RL, Gonzalez MI, Oktawiec J, Runčevski T, Xu J, Srebro-Hooper M, Milner PJ, Colwell KA, Autschbach J, Reimer JA, Long JR. Enantioselective Recognition of Ammonium Carbamates in a Chiral Metal-Organic Framework. J Am Chem Soc. 2017 Nov 8;139(44):16000-16012. doi: 10.1021/jacs.7b09983. Epub 2017 Oct 25. PubMed PMID: 28991466.

18: Werner M, Herling M, Garbe B, Theek C, Tronnier H, Heinrich U, Braun N. Determination of the Influence of the Antiphlogistic Ingredients Panthenol and Bisabolol on the SPF Value in vivo. Skin Pharmacol Physiol. 2017;30(6):284-291. doi: 10.1159/000480301. Epub 2017 Oct 4. PubMed PMID: 28972949.

19: Yildirim G, Kumral TL, Altindağ C, Özdemir E, Uyar Y. The Effect of Dexpanthenol-Vitamin A (Nazalnem) on Silastic Splints After Nasal Septal Surgery. J Craniofac Surg. 2017 Nov;28(8):2139-2142. doi: 10.1097/SCS.0000000000003983. PubMed PMID: 28938325.

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