WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 563993
CAS#: 960119-75-9
Description: Fc11a-2 is a specific inhibitor of inflammasome assembly, targeting the NLRP3 inflammasome by interfering with the proximity-induced autocleavage of procaspase-1.
MedKoo Cat#: 563993
Name: Fc11a-2
CAS#: 960119-75-9
Chemical Formula: C16H16N2
Exact Mass: 236.1313
Molecular Weight: 236.32
Elemental Analysis: C, 81.32; H, 6.82; N, 11.85
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Synonym: Fc11a-2; Fc11a2; Fc11a 2
IUPAC/Chemical Name: 1-Ethyl-5-methyl-2-phenyl-1H-benzo[d]imidazole
InChi Key: LAPXJMHYUYXOQN-UHFFFAOYSA-N
InChi Code: InChI=1S/C16H16N2/c1-3-18-15-10-9-12(2)11-14(15)17-16(18)13-7-5-4-6-8-13/h4-11H,3H2,1-2H3
SMILES Code: CC1=CC=C2N(CC)C(C3=CC=CC=C3)=NC2=C1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
The following data is based on the product molecular weight 236.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Liu W, Guo W, Wu J, Luo Q, Tao F, Gu Y, Shen Y, Li J, Tan R, Xu Q, Sun Y. A novel benzo[d]imidazole derivate prevents the development of dextran sulfate sodium-induced murine experimental colitis via inhibition of NLRP3 inflammasome. Biochem Pharmacol. 2013 May 15;85(10):1504-12. doi: 10.1016/j.bcp.2013.03.008. Epub 2013 Mar 15. PubMed PMID: 23506741.
