Valencene
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 341379

CAS#: 4630-07-3

Description: Valencene is a sesquiterpene that is an aroma component of citrus fruit and citrus-derived odorants.


Price and Availability

Size
Price

5g
USD 250
500g
USD 4650
Size
Price

25g
USD 695
Size
Price

100g
USD 1450

Valencene purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 341379
Name: Valencene
CAS#: 4630-07-3
Chemical Formula: C15H24
Exact Mass: 204.1878
Molecular Weight: 204.357
Elemental Analysis: C, 88.16; H, 11.84


Synonym: Valencene; NSC 148969; NSC-148969; NSC148969.

IUPAC/Chemical Name: Naphthalene, 1,2,3,5,6,7,8,8a-octahydro-1,8a-dimethyl-7-(1-methylethenyl)-, (1R,7R,8aS)-

InChi Key: QEBNYNLSCGVZOH-NFAWXSAZSA-N

InChi Code: InChI=1S/C15H24/c1-11(2)13-8-9-14-7-5-6-12(3)15(14,4)10-13/h7,12-13H,1,5-6,8-10H2,2-4H3/t12-,13-,15+/m1/s1

SMILES Code: C=C([C@@H]1CCC2=CCC[C@@H](C)[C@]2(C)C1)C


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
2934.99.03.00


References

1: Henke NA, Frohwitter J, Peters-Wendisch P, Wendisch VF. Carotenoid Production by Recombinant Corynebacterium glutamicum: Strain Construction, Cultivation, Extraction, and Quantification of Carotenoids and Terpenes. Methods Mol Biol. 2018;1852:127-141. doi: 10.1007/978-1-4939-8742-9_8. PubMed PMID: 30109629.

2: Api AM, Belsito D, Botelho D, Bruze M, Burton GA Jr, Buschmann J, Dagli ML, Date M, Dekant W, Deodhar C, Francis M, Fryer AD, Jones L, Joshi K, La Cava S, Lapczynski A, Liebler DC, O'Brien D, Patel A, Penning TM, Ritacco G, Romine J, Sadekar N, Salvito D, Schultz TW, Sipes IG, Sullivan G, Thakkar Y, Tokura Y, Tsang S. RIFM fragrance ingredient safety assessment, Valencene, CAS Registry Number 4630-07-3. Food Chem Toxicol. 2018 Sep;118 Suppl 1:S141-S146. doi: 10.1016/j.fct.2018.06.047. Epub 2018 Jun 20. PubMed PMID: 29935246.

3: Zhang Q, Zheng Y, Hu X, Hu X, Lv W, Lv D, Chen J, Wu M, Song Q, Shentu J. Ethnopharmacological uses, phytochemistry, biological activities, and therapeutic applications of Alpinia oxyphylla Miquel: A review. J Ethnopharmacol. 2018 Oct 5;224:149-168. doi: 10.1016/j.jep.2018.05.002. Epub 2018 May 5. Review. PubMed PMID: 29738847.

4: Marques FM, Figueira MM, Schmitt EFP, Kondratyuk TP, Endringer DC, Scherer R, Fronza M. In vitro anti-inflammatory activity of terpenes via suppression of superoxide and nitric oxide generation and the NF-κB signalling pathway. Inflammopharmacology. 2018 Apr 19. doi: 10.1007/s10787-018-0483-z. [Epub ahead of print] PubMed PMID: 29675712.

5: Henke NA, Wichmann J, Baier T, Frohwitter J, Lauersen KJ, Risse JM, Peters-Wendisch P, Kruse O, Wendisch VF. Patchoulol Production with Metabolically Engineered Corynebacterium glutamicum. Genes (Basel). 2018 Apr 17;9(4). pii: E219. doi: 10.3390/genes9040219. PubMed PMID: 29673223; PubMed Central PMCID: PMC5924561.

6: Wei X, Song M, Chen C, Tong H, Liang G, Gmitter FG Jr. Juice volatile composition differences between Valencia orange and its mutant Rohde Red Valencia are associated with carotenoid profile differences. Food Chem. 2018 Apr 15;245:223-232. doi: 10.1016/j.foodchem.2017.10.066. Epub 2017 Oct 12. PubMed PMID: 29287364.

7: Kolwek J, Behrens C, Linke D, Krings U, Berger RG. Cell-free one-pot conversion of (+)-valencene to (+)-nootkatone by a unique dye-decolorizing peroxidase combined with a laccase from Funalia trogii. J Ind Microbiol Biotechnol. 2018 Feb;45(2):89-101. doi: 10.1007/s10295-017-1998-9. Epub 2017 Dec 22. PubMed PMID: 29270883.

8: Tisgratog R, Sukkanon C, Grieco JP, Sanguanpong U, Chauhan KR, Coats JR, Chareonviriyaphap T. Evaluation of the Constituents of Vetiver Oil Against Anopheles minimus (Diptera: Culicidae), a Malaria Vector in Thailand. J Med Entomol. 2018 Jan 10;55(1):193-199. doi: 10.1093/jme/tjx188. PubMed PMID: 29029183.

9: Alcoba AET, Melo DC, de Andrade PM, Dias HJ, Pagotti MC, Magalhães LG, Júnior WGF, Crotti AEM, Miranda MLD. Chemical composition and in vitro antileishmanial and cytotoxic activities of the essential oils of Ocotea dispersa (Nees) Mez and Ocotea odorifera (Vell) Rohwer (Lauraceae). Nat Prod Res. 2017 Oct 12:1-4. doi: 10.1080/14786419.2017.1385007. [Epub ahead of print] PubMed PMID: 29022353.

10: Ambrož M, Matoušková P, Skarka A, Zajdlová M, Žáková K, Skálová L. The Effects of Selected Sesquiterpenes from Myrica rubra Essential Oil on the Efficacy of Doxorubicin in Sensitive and Resistant Cancer Cell Lines. Molecules. 2017 Jun 20;22(6). pii: E1021. doi: 10.3390/molecules22061021. PubMed PMID: 28632185.

11: Zhang H, Xie Y, Liu C, Chen S, Hu S, Xie Z, Deng X, Xu J. Comprehensive comparative analysis of volatile compounds in citrus fruits of different species. Food Chem. 2017 Sep 1;230:316-326. doi: 10.1016/j.foodchem.2017.03.040. Epub 2017 Mar 10. PubMed PMID: 28407917.

12: Rahamooz Haghighi S, Asadi MH, Akrami H, Baghizadeh A. Anti-carcinogenic and anti-angiogenic properties of the extracts of Acorus calamus on gastric cancer cells. Avicenna J Phytomed. 2017 Mar-Apr;7(2):145-156. PubMed PMID: 28348970; PubMed Central PMCID: PMC5355820.

13: Silva DB, Weldegergis BT, Van Loon JJ, Bueno VH. Qualitative and Quantitative Differences in Herbivore-Induced Plant Volatile Blends from Tomato Plants Infested by Either Tuta absoluta or Bemisia tabaci. J Chem Ecol. 2017 Jan;43(1):53-65. doi: 10.1007/s10886-016-0807-7. Epub 2017 Jan 3. PubMed PMID: 28050733; PubMed Central PMCID: PMC5331093.

14: Yang IJ, Lee DU, Shin HM. Inhibitory Effect of Valencene on the Development of Atopic Dermatitis-Like Skin Lesions in NC/Nga Mice. Evid Based Complement Alternat Med. 2016;2016:9370893. doi: 10.1155/2016/9370893. Epub 2016 Aug 18. PubMed PMID: 27630735; PubMed Central PMCID: PMC5007308.

15: Binder D, Frohwitter J, Mahr R, Bier C, Grünberger A, Loeschcke A, Peters-Wendisch P, Kohlheyer D, Pietruszka J, Frunzke J, Jaeger KE, Wendisch VF, Drepper T. Light-Controlled Cell Factories: Employing Photocaged Isopropyl-β-d-Thiogalactopyranoside for Light-Mediated Optimization of lac Promoter-Based Gene Expression and (+)-Valencene Biosynthesis in Corynebacterium glutamicum. Appl Environ Microbiol. 2016 Sep 30;82(20):6141-6149. Print 2016 Oct 15. PubMed PMID: 27520809; PubMed Central PMCID: PMC5068161.

16: Mohadjerani M, Hosseinzadeh R, Hosseini M. Chemical composition and antibacterial properties of essential oil and fatty acids of different parts of Ligularia persica Boiss. Avicenna J Phytomed. 2016 May-Jun;6(3):357-65. PubMed PMID: 27462560; PubMed Central PMCID: PMC4930544.

17: Bazzali O, Thai TH, Hoi TM, Khang NS, Hien NT, Casanova J, Bighelli A, Tomi F. Integrated Analysis of the Wood Oil from Xanthocyparis vietnamensis Farjon & Hiep. by Chromatographic and Spectroscopic Techniques. Molecules. 2016 Jun 27;21(7). pii: E840. doi: 10.3390/molecules21070840. PubMed PMID: 27355937.

18: Federman C, Ma C, Biswas D. Major components of orange oil inhibit Staphylococcus aureus growth and biofilm formation, and alter its virulence factors. J Med Microbiol. 2016 Jul;65(7):688-95. doi: 10.1099/jmm.0.000286. Epub 2016 Jun 3. PubMed PMID: 27259704.

19: Shen SL, Yin XR, Zhang B, Xie XL, Jiang Q, Grierson D, Chen KS. CitAP2.10 activation of the terpene synthase CsTPS1 is associated with the synthesis of (+)-valencene in 'Newhall' orange. J Exp Bot. 2016 Jul;67(14):4105-15. doi: 10.1093/jxb/erw189. Epub 2016 May 18. PubMed PMID: 27194737; PubMed Central PMCID: PMC5301923.

20: Nam JH, Nam DY, Lee DU. Valencene from the Rhizomes of Cyperus rotundus Inhibits Skin Photoaging-Related Ion Channels and UV-Induced Melanogenesis in B16F10 Melanoma Cells. J Nat Prod. 2016 Apr 22;79(4):1091-6. doi: 10.1021/acs.jnatprod.5b01127. Epub 2016 Mar 11. PubMed PMID: 26967731.