Vintriptol

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MedKoo CAT#: 341360

CAS#: 81600-06-8

Description: Vintriptol is a biochemical.


Price and Availability

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Pricing updated 2020-09-27. Prices are subject to change without notice.

Vintriptol is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 341360
Name: Vintriptol
CAS#: 81600-06-8
Chemical Formula: C56H68N6O9
Exact Mass: 968.5048
Molecular Weight: 969.193
Elemental Analysis: C, 69.40; H, 7.07; N, 8.67; O, 14.86


Synonym: Vintriptol; Vintriptolum.

IUPAC/Chemical Name: Vincaleukoblastine, O(sup 4)-deacetyl-3-de(methoxycarbonyl)-3-(((2-ethoxy-1-(1H-indol-3-ylmethyl)-2-oxoethyl)amino)carbonyl)-, (23(S))-

InChi Key: CC[C@@]1(C[C@H]2C[C@@](c3c(c4ccccc4[nH]3)CCN(C2)C1)(c5cc6c(cc5OC)N([C@@H]7[C@]68CCN9[C@H]8[C@@](C=CC9)([C@H]([C@@]7(C(=O)N[C@@H](Cc1c[nH]c2c1cccc2)C(=O)OCC)O)O)CC)C)C(=O)OC)O

InChi Code: CC[C@@]1(C[C@H]2C[C@@](c3c(c4ccccc4[nH]3)CCN(C2)C1)(c5cc6c(cc5OC)N([C@@H]7[C@]68CCN9[C@H]8[C@@](C=CC9)([C@H]([C@@]7(C(=O)N[C@@H](Cc1c[nH]c2c1cccc2)C(=O)OCC)O)O)CC)C)C(=O)OC)O

SMILES Code: CC[C@@]1(C[C@H]2C[C@@](c3c(c4ccccc4[nH]3)CCN(C2)C1)(c5cc6c(cc5OC)N([C@@H]7[C@]68CCN9[C@H]8[C@@](C=CC9)([C@H]([C@@]7(C(=O)N[C@@H](Cc1c[nH]c2c1cccc2)C(=O)OCC)O)O)CC)C)C(=O)OC)O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.03.00


References

1: Damen CW, Rosing H, Tibben MM, van Maanen MJ, Lagas JS, Schinkel AH, Schellens JH, Beijnen JH. A sensitive assay for the quantitative analysis of vinorelbine in mouse and human EDTA plasma by high-performance liquid chromatography coupled with electrospray tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2008 Jun 1;868(1-2):102-9. doi: 10.1016/j.jchromb.2008.04.046. Epub 2008 May 10. PubMed PMID: 18501686.

2: Budman DR. New vinca alkaloids and related compounds. Semin Oncol. 1992 Dec;19(6):639-45. Review. PubMed PMID: 1462165.

3: Boven E, Hendriks HR, Erkelens CA, Pinedo HM. The anti-tumour effects of the prodrugs N-l-leucyl-doxorubicin and vinblastine-isoleucinate in human ovarian cancer xenografts. Br J Cancer. 1992 Dec;66(6):1044-7. PubMed PMID: 1457343; PubMed Central PMCID: PMC1978011.

4: van Tellingen O, Beijnen JH, Baurain R, ten Bokkel Huinink WW, van der Woude HR, Nooyen WJ. Biodetermination of N-(deacetyl-O-4-vinblastoyl-23)-L-tryptophan, a metabolite of vintriptol, by high-performance liquid chromatography with fluorescence detection. J Chromatogr. 1992 Feb 14;574(2):293-8. PubMed PMID: 1618962.

5: Hendriks HR, Langdon S, Berger DP, Breistøl K, Fiebig HH, Fodstad O, Schwartsmann G. Comparative antitumour activity of vinblastine-isoleucinate and related vinca alkaloids in human tumour xenografts. Eur J Cancer. 1992;28A(4-5):767-73. PubMed PMID: 1524896.

6: Oosterkamp HM, Vlasveld LT, Wanders J, Beijnen JH, van Tellingen O, Dubbelman AC, Simonetti GP, Franklin HR, Vermorken JB, Ten Bokkel Huinink WW. Phase I study of vintriptol, a tryptophan ester of vinblastine. Eur J Cancer. 1991;27(10):1222-6. PubMed PMID: 1835590.

7: van Tellingen O, van der Woude HR, Beijnen JH, Rao KS, ten Bokkel Huinink WW, Nooyen WJ. High-performance liquid chromatographic bio-analysis and preliminary pharmacokinetics of the experimental antitumour drug vintriptol. J Chromatogr. 1990 Aug 3;529(2):329-38. PubMed PMID: 2229252.

8: Ceulemans F, Humblet Y, Bosly A, Symann M, Trouet A. A phase I study of vinblastine tryptophan ester. Cancer Chemother Pharmacol. 1986;18(1):44-6. PubMed PMID: 3757158.