WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 563918
Description: JCC76 is a selective inhibitor of heat shock protein 27 (Hsp27). JCC76 inhibits the proliferation of human epidermal growth factor 2 (Her2).
MedKoo Cat#: 563918
Chemical Formula: C24H32N2O4S
Exact Mass: 444.2083
Molecular Weight: 444.59
Elemental Analysis: C, 64.84; H, 7.26; N, 6.30; O, 14.39; S, 7.21
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
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Synonym: JCC76; JCC-76; JCC 76
IUPAC/Chemical Name: N-[3-[(2,5-Dimethylphenyl)methoxy]-4-[methyl(methylsulfonyl)amino]phenyl]cyclohexanecarboxamide
InChi Key: NLBGXSHIKISRHR-UHFFFAOYSA-N
InChi Code: InChI=1S/C24H32N2O4S/c1-17-10-11-18(2)20(14-17)16-30-23-15-21(12-13-22(23)26(3)31(4,28)29)25-24(27)19-8-6-5-7-9-19/h10-15,19H,5-9,16H2,1-4H3,(H,25,27)
SMILES Code: O=C(C1CCCCC1)NC2=CC=C(N(C)S(=O)(C)=O)C(OCC3=CC(C)=CC=C3C)=C2
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
The following data is based on the product molecular weight 444.59 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Zhao A, Zheng Q, Orahoske CM, Idippily ND, Ashcraft MM, Quamine A, Su B. Synthesis and biological evaluation of anti-cancer agents that selectively inhibit Her2 over-expressed breast cancer cell growth via down-regulation of Her2 protein. Bioorg Med Chem Lett. 2018 Feb 15;28(4):727-731. doi: 10.1016/j.bmcl.2018.01.016. Epub 2018 Jan 12. PubMed PMID: 29352646.
2: Voggu RR, Alagandula R, Zhou X, Su B, Zhong B, Guo B. A rapid LC-MS/MS method for quantification of CSUOH0901, a novel antitumor agent, in rat plasma. Biomed Chromatogr. 2015 May;29(5):797-802. doi: 10.1002/bmc.3365. Epub 2014 Nov 26. PubMed PMID: 25424731.
3: Cai X, Zhong B, Su B, Xu S, Guo B. Development and validation of a rapid LC-MS/MS method for the determination of JCC76, a novel antitumor agent for breast cancer, in rat plasma and its application to a pharmacokinetics study. Biomed Chromatogr. 2012 Sep;26(9):1118-24. doi: 10.1002/bmc.1757. Epub 2011 Dec 27. PubMed PMID: 22213194.