M-525

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MedKoo CAT#: 563895

CAS#: 2173582-08-4

Description: M-525 is a first-in-class, highly potent, irreversible small-molecule inhibitor of the menin-MLL interaction.


Price and Availability

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Pricing updated 2020-09-29. Prices are subject to change without notice.

M-525 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 563895
Name: M-525
CAS#: 2173582-08-4
Chemical Formula: C38H52FN5O6S
Exact Mass: 725.3622
Molecular Weight: 725.92
Elemental Analysis: C, 62.87; H, 7.22; F, 2.62; N, 9.65; O, 13.22; S, 4.42


Synonym: M-525; M525; M 525

IUPAC/Chemical Name: Methyl ((1S,2S)-2-((S)-(1-((1-(4-((1-((E)-4-(dimethylamino)but-2-enoyl)azetidin-3-yl)sulfonyl)phenyl)azetidin-3-yl)methyl)piperidin-4-yl)(3-fluorophenyl)(hydroxy)methyl)cyclopentyl)carbamate

InChi Key: FNGKXBSQGMOHOA-KZPMWZLFSA-N

InChi Code: InChI=1S/C38H52FN5O6S/c1-41(2)18-6-11-36(45)44-25-33(26-44)51(48,49)32-14-12-31(13-15-32)43-23-27(24-43)22-42-19-16-28(17-20-42)38(47,29-7-4-8-30(39)21-29)34-9-5-10-35(34)40-37(46)50-3/h4,6-8,11-15,21,27-28,33-35,47H,5,9-10,16-20,22-26H2,1-3H3,(H,40,46)/b11-6+/t34-,35-,38+/m0/s1

SMILES Code: O=C(OC)N[C@@H]1[C@@H]([C@](C2=CC=CC(F)=C2)(C3CCN(CC4CN(C5=CC=C(S(=O)(C6CN(C(/C=C/CN(C)C)=O)C6)=O)C=C5)C4)CC3)O)CCC1


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Xu S, Aguilar A, Xu T, Zheng K, Huang L, Stuckey J, Chinnaswamy K, Bernard D, Fernández-Salas E, Liu L, Wang M, McEachern D, Przybranowski S, Foster C, Wang S. Design of the First-in-Class, Highly Potent Irreversible Inhibitor Targeting the Menin-MLL Protein-Protein Interaction. Angew Chem Int Ed Engl. 2018 Feb 5;57(6):1601-1605. doi: 10.1002/anie.201711828. Epub 2018 Jan 15. PubMed PMID: 29284071.