M-525

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 563895

CAS#: 2173582-08-4

Description: M-525 is a first-in-class, highly potent, irreversible small-molecule inhibitor of the menin-MLL interaction.


Chemical Structure

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M-525
CAS# 2173582-08-4

Theoretical Analysis

MedKoo Cat#: 563895
Name: M-525
CAS#: 2173582-08-4
Chemical Formula: C38H52FN5O6S
Exact Mass: 725.36
Molecular Weight: 725.920
Elemental Analysis: C, 62.87; H, 7.22; F, 2.62; N, 9.65; O, 13.22; S, 4.42

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: M-525; M525; M 525

IUPAC/Chemical Name: Methyl ((1S,2S)-2-((S)-(1-((1-(4-((1-((E)-4-(dimethylamino)but-2-enoyl)azetidin-3-yl)sulfonyl)phenyl)azetidin-3-yl)methyl)piperidin-4-yl)(3-fluorophenyl)(hydroxy)methyl)cyclopentyl)carbamate

InChi Key: FNGKXBSQGMOHOA-KZPMWZLFSA-N

InChi Code: InChI=1S/C38H52FN5O6S/c1-41(2)18-6-11-36(45)44-25-33(26-44)51(48,49)32-14-12-31(13-15-32)43-23-27(24-43)22-42-19-16-28(17-20-42)38(47,29-7-4-8-30(39)21-29)34-9-5-10-35(34)40-37(46)50-3/h4,6-8,11-15,21,27-28,33-35,47H,5,9-10,16-20,22-26H2,1-3H3,(H,40,46)/b11-6+/t34-,35-,38+/m0/s1

SMILES Code: O=C(OC)N[C@@H]1[C@@H]([C@](C2=CC=CC(F)=C2)(C3CCN(CC4CN(C5=CC=C(S(=O)(C6CN(C(/C=C/CN(C)C)=O)C6)=O)C=C5)C4)CC3)O)CCC1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 725.92 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Xu S, Aguilar A, Xu T, Zheng K, Huang L, Stuckey J, Chinnaswamy K, Bernard D, Fernández-Salas E, Liu L, Wang M, McEachern D, Przybranowski S, Foster C, Wang S. Design of the First-in-Class, Highly Potent Irreversible Inhibitor Targeting the Menin-MLL Protein-Protein Interaction. Angew Chem Int Ed Engl. 2018 Feb 5;57(6):1601-1605. doi: 10.1002/anie.201711828. Epub 2018 Jan 15. PubMed PMID: 29284071.