P516-0475

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 563852

CAS#: 1359627-33-0

Description: P516-0475 is a novel chemical inducer of Streptococcus quorum sensing acts by inhibiting the pheromone-degrading endopeptidase PepO. This compound induces quorum sensing by stabilizing SHP pheromones in culture.


Price and Availability

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P516-0475 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 563852
Name: P516-0475
CAS#: 1359627-33-0
Chemical Formula: C15H17N5O3
Exact Mass: 315.1331
Molecular Weight: 315.33
Elemental Analysis: C, 57.13; H, 5.43; N, 22.21; O, 15.22


Synonym: P516-0475; P5160475; P516 0475; P-5160475; P 5160475

IUPAC/Chemical Name: N-(3-Methoxypropyl)-7-methyl-4-oxo-4,5-dihydro-[1,2,3]triazolo[1,5-a]quinoxaline-3-carboxamide

InChi Key: IFMRJCJHUJEJJY-UHFFFAOYSA-N

InChi Code: InChI=1S/C15H17N5O3/c1-9-4-5-11-10(8-9)17-15(22)13-12(18-19-20(11)13)14(21)16-6-3-7-23-2/h4-5,8H,3,6-7H2,1-2H3,(H,16,21)(H,17,22)

SMILES Code: O=C(C1=C2N(N=N1)C3=C(C=C(C)C=C3)NC2=O)NCCCOC


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
2934.99.03.00


References

1: Pérez Morales TG, Ratia K, Wang DS, Gogos A, Bloem L, Driver TG, Federle MJ. A novel chemical inducer of Streptococcus quorum sensing acts by inhibiting the pheromone-degrading endopeptidase PepO. J Biol Chem. 2018 Jan 19;293(3):931-940. doi: 10.1074/jbc.M117.810994. Epub 2017 Dec 4. Erratum in: J Biol Chem. 2018 Mar 23;293(12 ):4580. Bloem, Laura [author added];. PubMed PMID: 29203527; PubMed Central PMCID: PMC5777264.