DC92-B

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 581284

CAS#: 116988-30-8

Description: DC92-B is a new antitumor antibiotic from Actinomadura.


Chemical Structure

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DC92-B
CAS# 116988-30-8

Theoretical Analysis

MedKoo Cat#: 581284
Name: DC92-B
CAS#: 116988-30-8
Chemical Formula: C42H52N2O12
Exact Mass: 776.35
Molecular Weight: 776.880
Elemental Analysis: C, 64.93; H, 6.75; N, 3.61; O, 24.71

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: DC92-B; DC92 B; DC92B; DC 92-B; DC-92B; DC-92-B; DC 92-B;

IUPAC/Chemical Name: 10-((2S,4R,5S,6S)-4-(dimethylamino)-5,6-dihydroxy-4,6-dimethyltetrahydro-2H-pyran-2-yl)-8-((2S,4R,5R,6R)-4-(dimethylamino)-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)-11-hydroxy-5-methyl-2-((2S,2'R,3S)-3,3',3'-trimethyl-[2,2'-bioxiran]-3-yl)-4H-naphtho[2,3-h]chromene-4,7,12-trione

InChi Key: SCWWNJYIUMBQKK-RPPIAGSOSA-N

InChi Code: InChI=1S/C42H52N2O12/c1-17-12-21-29(35-27(17)23(45)15-26(53-35)41(6)37(56-41)36-39(3,4)55-36)34(49)30-28(33(21)48)19(24-14-22(43(8)9)31(46)18(2)52-24)13-20(32(30)47)25-16-40(5,44(10)11)38(50)42(7,51)54-25/h12-13,15,18,22,24-25,31,36-38,46-47,50-51H,14,16H2,1-11H3/t18-,22-,24+,25+,31+,36-,37+,38+,40-,41-,42+/m1/s1

SMILES Code: c1([C@@H]2C[C@@]([C@@H]([C@@](O2)(C)O)O)(C)N(C)C)cc(c2C(c3c(c4c(c(C)c3)c(cc([C@@]3([C@@H](O3)[C@@H]3C(O3)(C)C)C)o4)=O)C(c2c1O)=O)=O)[C@@H]1C[C@@H](N(C)C)[C@@H](O)[C@@H](C)O1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 776.88 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Kuwabara T, Noda T, Ohtake H, Ohtake T, Toyama S, Ikariyama Y. Classification of DNA-binding mode of antitumor and antiviral agents by the electrochemiluminescence of ruthenium complex. Anal Biochem. 2003 Mar 1;314(1):30-7. PubMed PMID: 12633599.

2: Murray V, Moore AG, Matias C, Wickham G. The interaction of hedamycin and DC92-B in a sequence selective manner with DNA in intact human cells. Biochim Biophys Acta. 1995 Apr 4;1261(2):195-200. PubMed PMID: 7711062.

3: Prakash AS, Moore AG, Murray V, Matias C, McFadyen WD, Wickham G. Comparison of the sequence selectivity of the DNA-alkylating pluramycin antitumour antibiotics DC92-B and hedamycin. Chem Biol Interact. 1995 Mar 30;95(1-2):17-28. PubMed PMID: 7697748.

4: Sun D, Hansen M, Clement JJ, Hurley LH. Structure of the altromycin B (N7-guanine)-DNA adduct. A proposed prototypic DNA adduct structure for the pluramycin antitumor antibiotics. Biochemistry. 1993 Aug 17;32(32):8068-74. PubMed PMID: 8347608.

5: Yasuzawa T, Saitoh Y, Sano H. Structures of the novel anthraquinone antitumor antibiotics, DC92-B and DC92-D. J Antibiot (Tokyo). 1990 May;43(5):485-91. PubMed PMID: 2358401.

6: Takahashi I, Takahashi K, Asano K, Kawamoto I, Yasuzawa T, Ashizawa T, Tomita F, Nakano H. DC92-B, a new antitumor antibiotic from Actinomadura. J Antibiot (Tokyo). 1988 Aug;41(8):1151-3. PubMed PMID: 3170349.