WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 584545
Description: Jedi2 is a Piezo1 channel activator that promotes Ca2+ influx into HEK293 cells expressing Piezo1 channels and elicits responses in mouse Piezo1-transfected, but not Piezo2-transfected cells.
MedKoo Cat#: 584545
Chemical Formula: C10H8O3S
Exact Mass: 208.0194
Molecular Weight: 208.231
Elemental Analysis: C, 57.68; H, 3.87; O, 23.05; S, 15.40
IUPAC/Chemical Name: 2-Methyl-5-(2-thienyl)-3-furancarboxylic acid
InChi Key: YXDCRSXNEOKXDE-UHFFFAOYSA-N
InChi Code: InChI=1S/C10H8O3S/c1-6-7(10(11)12)5-8(13-6)9-3-2-4-14-9/h2-5H,1H3,(H,11,12)
SMILES Code: O=C(C1=C(C)OC(C2=CC=CS2)=C1)O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
The following data is based on the product molecular weight 208.231 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
Wang et al (2018) A lever-like transduction pathway for long-distance chemical- and mechano-gating of the mechanosensitive Piezo1 channel. Nat.Commun. 9 1300 PMID: 29610524