VU6007477

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MedKoo CAT#: 555316

CAS#: 2220141-46-6

Description: VU6007477 is a novel M1 PAM. VU6007477 resulted in good rat M1 PAM potency (EC50 = 230 nM, 93% ACh max), minimal M1 agonist activity (agonist EC50 > 10 μM), good CNS penetration (rat brain/plasma Kp = 0.28, Kp,uu = 0.32; mouse Kp = 0.16, Kp,uu = 0.18), and no cholinergic adverse events (AEs, e.g., seizures).


Price and Availability

Size Price Shipping out time Quantity
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Pricing updated 2020-10-26. Prices are subject to change without notice.

VU6007477 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 555316
Name: VU6007477
CAS#: 2220141-46-6
Chemical Formula: C24H26N6O2
Exact Mass: 430.2117
Molecular Weight: 430.512
Elemental Analysis: C, 66.96; H, 6.09; N, 19.52; O, 7.43


Synonym: VU6007477; VU-6007477; VU 6007477

IUPAC/Chemical Name: 1-methyl-4-((6-(1-methyl-1H-pyrazol-4-yl)pyridin-3-yl)methyl)-N-(tetrahydro-2H-pyran-4-yl)-1Hpyrrolo[2,3-b]pyridine-6-carboxamide

InChi Key: OYSPYZFYHUIBOS-UHFFFAOYSA-N

InChi Code: InChI=1S/C24H26N6O2/c1-29-8-5-20-17(11-16-3-4-21(25-13-16)18-14-26-30(2)15-18)12-22(28-23(20)29)24(31)27-19-6-9-32-10-7-19/h3-5,8,12-15,19H,6-7,9-11H2,1-2H3,(H,27,31)

SMILES Code: O=C(C1=CC(CC2=CC=C(C3=CN(C)N=C3)N=C2)=C4C(N(C)C=C4)=N1)NC5CCOCC5


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

VU6007477, a Novel M1 PAM Based on a Pyrrolo[2,3-b]pyridine Carboxamide Core Devoid of Cholinergic Adverse Events
Julie L. Engers, Elizabeth S. Childress, Madeline F. Long, Rory A. Capstick, Vincent B. Luscombe, Hekyung P. Cho, Jonathan W. Dickerson, Jerri M. Rook, Anna L. Blobaum, Colleen M. Niswender, Darren W. Engers, P. Jeffrey Conn, and Craig W. Lindsley
Publication Date (Web): September 4, 2018 (Letter)
DOI: 10.1021/acsmedchemlett.8b00261