CA-074
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 563809

CAS#: 134448-10-5

Description: CA-074 is a potent and selective inhibitor of cathepsin B.


Price and Availability

Size
Price

5mg
USD 560
Size
Price

Size
Price

CA-074, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 563809
Name: CA-074
CAS#: 134448-10-5
Chemical Formula: C18H29N3O6
Exact Mass: 383.2056
Molecular Weight: 383.45
Elemental Analysis: C, 56.38; H, 7.62; N, 10.96; O, 25.03


Synonym: CA-074; CA074; CA 074

IUPAC/Chemical Name: (2S-trans)-1-(N-((3-((Propylamino)carbonyl)oxiranyl)carbonyl)-L-isoleucyl)-L-proline; (2S)-1-[(2S,3S)-3-Methyl-2-[[(3S)-3-(propylcarbamoyl)oxirane-2-carbonyl]amino]pentanoyl]pyrrolidine-2-carboxylic acid

InChi Key: ZEZGJKSEBRELAS-PEDHHIEDSA-N

InChi Code: InChI=1S/C18H29N3O6/c1-4-8-19-15(22)13-14(27-13)16(23)20-12(10(3)5-2)17(24)21-9-6-7-11(21)18(25)26/h10-14H,4-9H2,1-3H3,(H,19,22)(H,20,23)(H,25,26)/t10-,11-,12-,13-,14-/m0/s1

SMILES Code: O=C(O)[C@H]1N(C([C@H]([C@@H](C)CC)NC([C@H]2O[C@@H]2C(NCCC)=O)=O)=O)CCC1


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
2934.99.03.00


References

1: Mihalik R, Imre G, Petak I, Szende B, Kopper L. Cathepsin B-independent abrogation of cell death by CA-074-OMe upstream of lysosomal breakdown. Cell Death Differ. 2004 Dec;11(12):1357-60. PubMed PMID: 15297886.

2: Montaser M, Lalmanach G, Mach L. CA-074, but not its methyl ester CA-074Me, is a selective inhibitor of cathepsin B within living cells. Biol Chem. 2002 Jul-Aug;383(7-8):1305-8. PubMed PMID: 12437121.

3: Tohyama T, Kiyochi H, Narumoto K, Honda K, Kobayashi N, Kanoh M, Saibara T, Katunuma N. Inhibitory effect of cathepsin B inhibitor CA 074 on mouse anti-rat mixed lymphocyte reaction: novel immunosuppressive strategy for indirect xenoantigen recognition. Transplant Proc. 2000 Aug;32(5):944-5. PubMed PMID: 10936287.

4: Yamashima T, Kohda Y, Tsuchiya K, Ueno T, Yamashita J, Yoshioka T, Kominami E. Inhibition of ischaemic hippocampal neuronal death in primates with cathepsin B inhibitor CA-074: a novel strategy for neuroprotection based on 'calpain-cathepsin hypothesis'. Eur J Neurosci. 1998 May;10(5):1723-33. Erratum in: Eur J Neurosci 1998 Sep;10(9):3034. PubMed PMID: 9751144.

5: Werle B, Ebert W, Klein W, Spiess E. Assessment of cathepsin L activity by use of the inhibitor CA-074 compared to cathepsin B activity in human lung tumor tissue. Biol Chem Hoppe Seyler. 1995 Mar;376(3):157-64. PubMed PMID: 7612192.