D-Lin-MC3-DMA
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 555308

CAS#: 1224606-06-7

Description: D-Lin-MC3-DMA is the most potent cationic lipid that has been synthesized for Lipid nanoparticles (LNPs) to deliver the siRNA. D-Lin-MC3-DMA is useful for design of lipid nanoparticles for in vitro and in vivo delivery of plasmid DNA. LNP systems containing D-Lin-MC3-DMA can be highly effective, non-toxic pDNA delivery systems for gene expression both in vitro and in vivo.


Price and Availability

Size
Price

5mg
USD 150
50mg
USD 750
500mg
USD 2650
Size
Price

10mg
USD 250
100mg
USD 1250
1g
USD 3450
Size
Price

25mg
USD 450
200mg
USD 1950
2g
USD 5950

D-Lin-MC3-DMA, purity > 98%, is in stock. The same day shipping out after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 555308
Name: D-Lin-MC3-DMA
CAS#: 1224606-06-7
Chemical Formula: C43H79NO2
Exact Mass: 641.6111
Molecular Weight: 642.11
Elemental Analysis: C, 80.43; H, 12.40; N, 2.18; O, 4.98


Synonym: D-Lin-MC3-DMA; DLin-MC3-DMA; Dlin-mc3-dma;

IUPAC/Chemical Name: (6Z,9Z,28Z,31Z)-Heptatriaconta-6,9,28,31-tetraen-19-yl 4-(dimethylamino)butanoate

InChi Key: NRLNQCOGCKAESA-KWXKLSQISA-N

InChi Code: InChI=1S/C43H79NO2/c1-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-35-38-42(46-43(45)40-37-41-44(3)4)39-36-34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-2/h13-16,19-22,42H,5-12,17-18,23-41H2,1-4H3/b15-13-,16-14-,21-19-,22-20-

SMILES Code: O=C(OC(CCCCCCCC/C=C\C/C=C\CCCCC)CCCCCCCC/C=C\C/C=C\CCCCC)CCCN(C)C


Technical Data

Appearance:
Colorless to light yellow liquid

Purity:
>98% (or refer to the Certificate of Analysis)

Certificate of Analysis:

Safety Data Sheet (MSDS):

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
2934.99.03.00


References

1: Yanez Arteta M, Kjellman T, Bartesaghi S, Wallin S, Wu X, Kvist AJ, Dabkowska
A, Székely N, Radulescu A, Bergenholtz J, Lindfors L. Successful reprogramming of
cellular protein production through mRNA delivered by functionalized lipid
nanoparticles. Proc Natl Acad Sci U S A. 2018 Apr 10;115(15):E3351-E3360. doi:
10.1073/pnas.1720542115. Epub 2018 Mar 27. PubMed PMID: 29588418; PubMed Central
PMCID: PMC5899464.

2: Viger-Gravel J, Schantz A, Pinon AC, Rossini AJ, Schantz S, Emsley L.
Structure of Lipid Nanoparticles Containing siRNA or mRNA by Dynamic Nuclear
Polarization-Enhanced NMR Spectroscopy. J Phys Chem B. 2018 Feb
22;122(7):2073-2081. doi: 10.1021/acs.jpcb.7b10795. Epub 2018 Feb 9. PubMed PMID:
29332384.

3: Kulkarni JA, Myhre JL, Chen S, Tam YYC, Danescu A, Richman JM, Cullis PR.
Design of lipid nanoparticles for in vitro and in vivo delivery of plasmid DNA.
Nanomedicine. 2017 May;13(4):1377-1387. doi: 10.1016/j.nano.2016.12.014. Epub
2016 Dec 28. PubMed PMID: 28038954.