4-Fluoro-thalidomide
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MedKoo CAT#: 584541

CAS#: 835616-60-9

Description: 4-Fluoro-thalidomide, also known as TC E3 5032, is a precursor to Pomalidomide-based PROTACs.


Chemical Structure

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4-Fluoro-thalidomide
CAS# 835616-60-9

Theoretical Analysis

MedKoo Cat#: 584541
Name: 4-Fluoro-thalidomide
CAS#: 835616-60-9
Chemical Formula: C13H9FN2O4
Exact Mass: 276.0546
Molecular Weight: 276.2234
Elemental Analysis: C, 56.53; H, 3.28; F, 6.88; N, 10.14; O, 23.17

Price and Availability

Size Price Availability Quantity
100.0mg USD 590.0 2 Weeks
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Synonym: TC E3 5032; TC E35032; TC E3-5032; TCE3 5032; TCE35032; TCE3-5032; 4-Fluoro-thalidomide;

IUPAC/Chemical Name: 2-(2,6-Dioxo-3-piperidinyl)-4-fluoro-1H-isoindole-1,3(2H)-dione

InChi Key: CRAUTELYXAAAPW-UHFFFAOYSA-N

InChi Code: InChI=1S/C13H9FN2O4/c14-7-3-1-2-6-10(7)13(20)16(12(6)19)8-4-5-9(17)15-11(8)18/h1-3,8H,4-5H2,(H,15,17,18)

SMILES Code: O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3F)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

Preparing Stock Solutions

The following data is based on the product molecular weight 276.2234 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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Remillard et al (2017) Degradation of the BAF complex factor BRD9 by heterobifunctional ligands. Angew.Chem.Int.Ed.Engl. 56 5738 PMID: 28418626