WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 206987
Description: VERU-111 is a novel, oral α and β tubulin inhibitor that blocks tubulin polymerization and is not a substrate for multi-drug resistance mechanisms. In xenograft models of taxane responsive and resistant cancers, VERU-111 results in almost complete tumor inhibition at ≤20 mg/kg orally dosed infrequently as 1/week. VERU-111 and docetaxel were tested in the human PCa model, 22Rv1 which expresses androgen receptor splice variants, including AR-V7, and is resistant to abiraterone and enzalutamide.
MedKoo Cat#: 206987
Chemical Formula: C21H19N3O4
Exact Mass: 377.1376
Molecular Weight: 377.4
Elemental Analysis: C, 66.83; H, 5.07; N, 11.13; O, 16.96
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Synonym: VERU-111; VERU 111; VERU111;
IUPAC/Chemical Name: (2-(1H-indol-3-yl)-1H-imidazol-4-yl)(3,4,5-trimethoxyphenyl)methanone
InChi Key: WQGVHOVEXMOLOK-UHFFFAOYSA-N
InChi Code: InChI=1S/C21H19N3O4/c1-26-17-8-12(9-18(27-2)20(17)28-3)19(25)16-11-23-21(24-16)14-10-22-15-7-5-4-6-13(14)15/h4-11,22H,1-3H3,(H,23,24)
SMILES Code: COC1=C(OC)C=C(C(C2=CNC(C3=CNC4=C3C=CC=C4)=N2)=O)C=C1OC
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
The following data is based on the product molecular weight 377.4 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Wang Q, Arnst K, Wang Y, Kumar G, Ma D, Chen H, Wu Z, Yang J, White SW, Miller
DD, Li W. Structural modification of the 3,4,5-trimethoxyphenyl moiety in the
tubulin inhibitor VERU-111 leads to improved antiproliferative activities. J Med
Chem. 2018 Aug 20. doi: 10.1021/acs.jmedchem.8b00827. [Epub ahead of print]
PubMed PMID: 30122035.