VERU-111

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 206987

CAS#: 1332881-26-1

Description: VERU-111 is a novel, oral α and β tubulin inhibitor that blocks tubulin polymerization and is not a substrate for multi-drug resistance mechanisms. In xenograft models of taxane responsive and resistant cancers, VERU-111 results in almost complete tumor inhibition at ≤20 mg/kg orally dosed infrequently as 1/week. VERU-111 and docetaxel were tested in the human PCa model, 22Rv1 which expresses androgen receptor splice variants, including AR-V7, and is resistant to abiraterone and enzalutamide.


Chemical Structure

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VERU-111
CAS# 1332881-26-1

Theoretical Analysis

MedKoo Cat#: 206987
Name: VERU-111
CAS#: 1332881-26-1
Chemical Formula: C21H19N3O4
Exact Mass: 377.1376
Molecular Weight: 377.4
Elemental Analysis: C, 66.83; H, 5.07; N, 11.13; O, 16.96

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: VERU-111; VERU 111; VERU111;

IUPAC/Chemical Name: (2-(1H-indol-3-yl)-1H-imidazol-4-yl)(3,4,5-trimethoxyphenyl)methanone

InChi Key: WQGVHOVEXMOLOK-UHFFFAOYSA-N

InChi Code: InChI=1S/C21H19N3O4/c1-26-17-8-12(9-18(27-2)20(17)28-3)19(25)16-11-23-21(24-16)14-10-22-15-7-5-4-6-13(14)15/h4-11,22H,1-3H3,(H,23,24)

SMILES Code: COC1=C(OC)C=C(C(C2=CNC(C3=CNC4=C3C=CC=C4)=N2)=O)C=C1OC

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

Preparing Stock Solutions

The following data is based on the product molecular weight 377.4 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Wang Q, Arnst K, Wang Y, Kumar G, Ma D, Chen H, Wu Z, Yang J, White SW, Miller
DD, Li W. Structural modification of the 3,4,5-trimethoxyphenyl moiety in the
tubulin inhibitor VERU-111 leads to improved antiproliferative activities. J Med
Chem. 2018 Aug 20. doi: 10.1021/acs.jmedchem.8b00827. [Epub ahead of print]
PubMed PMID: 30122035.