BTC-8

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MedKoo CAT#: 563798

CAS#: NONE

Description: BTC-8 is a BAX activator, which inhibits GBM cell proliferation, arrests the cell cycle, and induces apoptosis through the induction of mitochondrial membrane permeabilization. BTC-8 is demonstrated to block proliferation and self-renewal of GSCs and induce their apoptosis.


Price and Availability

Size Price Shipping out time Quantity
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Pricing updated 2020-03-30. Prices are subject to change without notice.

BTC-8 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 563798
Name: BTC-8
CAS#: NONE
Chemical Formula: C26H27N5O3
Exact Mass: 457.2114
Molecular Weight: 457.53
Elemental Analysis: C, 68.25; H, 5.95; N, 15.31; O, 10.49


Synonym: BTC-8; BTC8; BTC 8

IUPAC/Chemical Name: (E)-2-(4'-(Dimethylamino)-2-hydroxy-[1,1'-biphenyl]-4-yl)-4-(2-(2-ethoxyphenyl)hydrazineylidene)-5-methyl-2,4-dihydro-3H-pyrazol-3-one

InChi Key: ZWFLOKKJXCBWMS-AZPGRJICSA-N

InChi Code: InChI=1S/C26H27N5O3/c1-5-34-24-9-7-6-8-22(24)27-28-25-17(2)29-31(26(25)33)20-14-15-21(23(32)16-20)18-10-12-19(13-11-18)30(3)4/h6-16,27,32H,5H2,1-4H3/b28-25+

SMILES Code: O=C1N(C2=CC=C(C3=CC=C(N(C)C)C=C3)C(O)=C2)N=C(C)/C1=N\NC4=CC=CC=C4OCC


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.03.00


Additional Information

BTC-8 was demonstrated to sensitize both GBM cells and GSCs to the alkylating agent Temozolomide.


References

1: Daniele S, Pietrobono D, Costa B, Giustiniano M, La Pietra V, Giacomelli C, La Regina G, Silvestri R, Taliani S, Trincavelli ML, Da Settimo F, Novellino E, Martini C, Marinelli L. Bax Activation Blocks Self-Renewal and Induces Apoptosis of Human Glioblastoma Stem Cells. ACS Chem Neurosci. 2018 Jan 17;9(1):85-99. doi: 10.1021/acschemneuro.7b00023. Epub 2017 Apr 11. PubMed PMID: 28368610.