GCN2iB acetate

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 407925

CAS#: 2183470-13-3 (acetate)

Description: GCN2iB is a GCN2 inhibitor. GCN2iB may be useful for the treatment of cancer. The inhibition of GCN2 sensitizes cancer cells with low basal-level expression of asparagine synthetase (ASNS) to the antileukemic agent L-asparaginase (ASNase) in vitro and in vivo.

Chemical Structure

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GCN2iB acetate
CAS# 2183470-13-3 (acetate)
Instruction

Theoretical Analysis

MedKoo Cat#: 407925
Name: GCN2iB acetate
CAS#: 2183470-13-3 (acetate)
Chemical Formula: C20H16ClF2N5O5S
Exact Mass: 0.00
Molecular Weight: 511.885
Elemental Analysis: C, 46.93; H, 3.15; Cl, 6.93; F, 7.42; N, 13.68; O, 15.63; S, 6.26

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Related CAS #: 2183470-12-2 (free base), 2183470-13-3 (acetate),

Synonym: GCN2iB; GCN2iB acetate.

IUPAC/Chemical Name: N-(3-((2-aminopyrimidin-5-yl)ethynyl)-2,4-difluorophenyl)-5-chloro-2-methoxypyridine-3-sulfonamide acetic acid

InChi Key: QNHLMBSUYPVOLX-UHFFFAOYSA-N

InChi Code: InChI=1S/C18H12ClF2N5O3S.C2H4O2/c1-29-17-15(6-11(19)9-23-17)30(27,28)26-14-5-4-13(20)12(16(14)21)3-2-10-7-24-18(22)25-8-10;1-2(3)4/h4-9,26H,1H3,(H2,22,24,25);1H3,(H,3,4)

SMILES Code: O=S(C1=CC(Cl)=CN=C1OC)(NC2=CC=C(F)C(C#CC3=CN=C(N)N=C3)=C2F)=O.CC(O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Product Data:
Product Data
Instruction:
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Preparing Stock Solutions

The following data is based on the product molecular weight 511.884800000000000000000000000000 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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Inhibition of GCN2 sensitizes ASNS-low cancer cells to asparaginase by disrupting the amino acid response Akito Nakamura, Tadahiro Nambu, Shunsuke Ebara, Yuka Hasegawa, Kosei Toyoshima, Yasuko Tsuchiya, Daisuke Tomita, Jun Fujimoto, Osamu Kurasawa, Chisato Takahara, Ayumi Ando, Ryuichi Nishigaki, Yoshinori Satomi, Akito Hata, and Takahito Hara PNAS August 14, 2018. 115 (33) E7776-E7785; published ahead of print July 30, 2018. https://doi.org/10.1073/pnas.1805523115 Add to Cart ($10)