2-Iodobenzoic acid
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 558657

CAS#: 88-67-5

Description: 2-Iodobenzoic acid is an organic compound and the impact-sensitive intermediate in the synthesis of the Dess-Martin periodinane.

Chemical Structure

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2-Iodobenzoic acid
CAS# 88-67-5
Instruction

Theoretical Analysis

MedKoo Cat#: 558657
Name: 2-Iodobenzoic acid
CAS#: 88-67-5
Chemical Formula: C7H5IO2
Exact Mass: 247.93
Molecular Weight: 248.020
Elemental Analysis: C, 33.90; H, 2.03; I, 51.17; O, 12.90

Price and Availability

Size Price Availability Quantity
25g USD 200 2 Weeks
100g USD 350 2 Weeks
500g USD 610 2 Weeks
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Synonym: 2-Iodobenzoic acid; 2Iodobenzoic acid; 2 Iodobenzoic acid; o-Iodobenzoic acid; Kyselina o-jodbenzoova;

IUPAC/Chemical Name: 2-Iodobenzoic acid

InChi Key: CJNZAXGUTKBIHP-UHFFFAOYSA-N

InChi Code: InChI=1S/C7H5IO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,(H,9,10)

SMILES Code: O=C(O)C1=CC=CC=C1I

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 248.02 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Leogane O, Lebel H. One-pot multicomponent synthesis of indoles from 2-iodobenzoic acid. Angew Chem Int Ed Engl. 2008;47(2):350-2. Erratum in: Angew Chem Int Ed Engl. 2008;47(16):2907. PubMed PMID: 18038439.

2: Subramanian V, Batchu VR, Barange D, Pal M. Synthesis of isocoumarins via Pd/C-mediated reactions of o-iodobenzoic acid with terminal alkynes. J Org Chem. 2005 Jun 10;70(12):4778-83. PubMed PMID: 15932318.

3: Půlpánová J, Ledvina M, Chmelar V. [The effect of various doses of ionizing radiation on the excretion of o-iodobenzoic acid-125I and their conjugates in the urine of rats]. Sb Ved Pr Lek Fak Karlovy Univerzity Hradci Kralove Suppl. 1979;22(2):287-98. Czech. PubMed PMID: 317168.

4: Benesová-Půlpánová J, Ledvina M. [The efect of ionizing radiation and fasting on the excretion of o-iodobenzoic acid 125I and its conjugates in the urine of rats protected by radioprotective agents]. Sb Ved Pr Lek Fak Karlovy Univerzity Hradci Kralove Suppl. 1983;26(3):201-15. Czech. PubMed PMID: 6335783.

5: Bercovich CF, Pirola CJ, Finkielman S, Nahmod VE. Effects of sodium o-iodobenzoate on acid-base parameters and survival in dogs with hemorrhagic shock. Circ Shock. 1991 Feb;33(2):63-7. PubMed PMID: 2049815.

6: Wirz B, Suter F, Zuber H. Structure and function of L-lactate dehydrogenases from thermophilic and mesophilic bacteria. III) The primary structure of thermophilic lactate dehydrogenase from Bacillus stearothermophilus. Hydroxylamine-, o-iodosobenzoic acid- and tryptic-fragments. The complete amino-acid sequence. Hoppe Seylers Z Physiol Chem. 1983 Jul;364(7):893-909. PubMed PMID: 6352452.

7: Rafter GW, Blair JB. Reaction of liver pyruvate kinase with sulfhydryl reagents: effect on its activity. Biochim Biophys Acta. 1987 Jun 17;913(2):195-9. PubMed PMID: 3593739.

8: Láznícek M, Kvĕtina J, Srámek B, Kronrád L, Hradílek P. Distribution and elimination of o-125I-benzoate in rats. Gen Physiol Biophys. 1983 Aug;2(4):279-85. PubMed PMID: 6678770.

9: Kugimiya T, Suwa K, Inada Y, Mayuzumi K, Kasama T. Effects of drug-induced reduction in oxyhemoglobin affinity on survival time of mice in severe hypoxic conditions. Tohoku J Exp Med. 1984 Nov;144(3):315-20. PubMed PMID: 6523500.

10: Duhe RJ, Selman BR. The dithiothreitol-stimulated dissociation of the chloroplast coupling factor 1 epsilon-subunit is reversible. Biochim Biophys Acta. 1990 May 15;1017(1):70-8. PubMed PMID: 2140701.

11: Kugimiya T, Fujisawa M, Suwa K, Yamamura H, Minohara K, Kasama T. Effects of ortho-iodo-sodium benzoate (OISB) on oxygen-hemoglobin affinity and its relation to plasma concentrations in dogs. Tohoku J Exp Med. 1982 Jan;136(1):35-41. PubMed PMID: 7071828.

12: Kugimiya T, Gunst MA, Laver MB, Duvelleroy MA. Dependency of O2-affinity effects on O2 consumption in the isolated rat heart. Tohoku J Exp Med. 1983 Sep;141(1):47-59. PubMed PMID: 6636149.

13: Richter R, Láznícková A, Láznícek M, Kvĕtina J. [The mechanisms of elimination of o-125I-benzoate in rabbits]. Cesk Farm. 1990 Feb;39(1):11-4. Czech. PubMed PMID: 2379243.

14: Rude RE, Tumas J, Gunst M, Kloner RA, DeBoer LW, Maroko PR. Effects of ortho-iodo sodium benzoate on acute myocardial ischemia, hemodynamic function, and infarct size after coronary artery occlusion in dogs. Am J Cardiol. 1983 May 1;51(8):1422-7. PubMed PMID: 6846170.