WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 461902
Description: Warangalone is a prenylated isoflavone from the insecticidal plant Derris scandens that acts as a powerful inhibitor of protein kinase A.
MedKoo Cat#: 461902
Chemical Formula: C25H24O5
Exact Mass: 404.1624
Molecular Weight: 404.46
Elemental Analysis: C, 74.24; H, 5.98; O, 19.78
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
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Synonym: Warangalone; Scandenolone;
IUPAC/Chemical Name: 5-hydroxy-7-(4-hydroxyphenyl)-2,2-dimethyl-10-(3-methylbut-2-en-1-yl)-2H,6H-pyrano[3,2-g]chromen-6-one
InChi Key: HGHOPAZIUPORIN-UHFFFAOYSA-N
InChi Code: InChI=1S/C25H24O5/c1-14(2)5-10-18-23-17(11-12-25(3,4)30-23)21(27)20-22(28)19(13-29-24(18)20)15-6-8-16(26)9-7-15/h5-9,11-13,26-27H,10H2,1-4H3
SMILES Code: O=C1C(C(O)=C(C=CC(C)(C)O2)C2=C3C/C=C(C)\C)=C3OC=C1C4=CC=C(O)C=C4
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
The following data is based on the product molecular weight 404.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Wang BH, Ternai B, Polya G. Specific inhibition of cyclic AMP-dependent protein kinase by warangalone and robustic acid. Phytochemistry. 1997 Mar;44(5):787-96. PubMed PMID: 9115691.
2: Talla E, Njamen D, Mbafor JT, Fomum ZT, Kamanyi A, Mbanya JC, Giner RM, Recio MC, Máñez S, Ríos JL. Warangalone, the isoflavonoid anti-inflammatory principle of Erythrina addisoniae stem bark. J Nat Prod. 2003 Jun;66(6):891-3. PubMed PMID: 12828487.
3: Bae EY, Na M, Njamen D, Mbafor JT, Fomum ZT, Cui L, Choung DH, Kim BY, Oh WK, Ahn JS. Inhibition of protein tyrosine phosphatase 1B by prenylated isoflavonoids isolated from the stem bark of Erythrina addisoniae. Planta Med. 2006 Aug;72(10):945-8. PubMed PMID: 16972201.
4: Ito C, Murata T, Itoigawa M, Nakao K, Kumagai M, Kaneda N, Furukawa H. Induction of apoptosis by isoflavonoids from the leaves of Millettia taiwaniana in human leukemia HL-60 cells. Planta Med. 2006 Apr;72(5):424-9. PubMed PMID: 16557456.
5: Wang W, Liang H, Wang B, Tu GZ, Chen HB, Zhao YY. [A new natural product from the roots of Hedysarum multijugum]. Beijing Da Xue Xue Bao Yi Xue Ban. 2005 Oct 18;37(5):532-5. Chinese. PubMed PMID: 16224530.
6: Orazbekov Y, Ibrahim MA, Mombekov S, Srivedavyasasri R, Datkhayev U, Makhatov B, Chaurasiya ND, Tekwani BL, Ross SA. Isolation and Biological Evaluation of Prenylated Flavonoids from Maclura pomifera. Evid Based Complement Alternat Med. 2018 Jan 14;2018:1370368. doi: 10.1155/2018/1370368. eCollection 2018. PubMed PMID: 29552078; PubMed Central PMCID: PMC5820588.