Butylparaben

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 592979

CAS#: 94-26-8

Description: Butylparaben is an Antifungal Agent.


Chemical Structure

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Butylparaben
CAS# 94-26-8

Theoretical Analysis

MedKoo Cat#: 592979
Name: Butylparaben
CAS#: 94-26-8
Chemical Formula: C11H14O3
Exact Mass: 194.09
Molecular Weight: 194.230
Elemental Analysis: C, 68.02; H, 7.27; O, 24.71

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Butylparaben

IUPAC/Chemical Name: Benzoic acid, 4-hydroxy-, butyl ester

InChi Key: QFOHBWFCKVYLES-UHFFFAOYSA-N

InChi Code: InChI=1S/C11H14O3/c1-2-3-8-14-11(13)9-4-6-10(12)7-5-9/h4-7,12H,2-3,8H2,1H3

SMILES Code: O=C(OCCCC)C1=CC=C(O)C=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 194.23 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Manzetti S, Lu T. Addendum: Solvation Energies of Butylparaben, Benzo[a]pyrene diol epoxide, Perfluorooctanesulfonic acid, and DEHP in Complex with DNA Bases. Chem Res Toxicol. 2018 Aug 7. doi: 10.1021/acs.chemrestox.8b00180. [Epub ahead of print] PubMed PMID: 30080032.

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4: Kramer RD, Filippe TC, Prado MR, de Azevedo JCR. The influence of solid-liquid coefficient in the fate of pharmaceuticals and personal care products in aerobic wastewater treatment. Environ Sci Pollut Res Int. 2018 Jun 28. doi: 10.1007/s11356-018-2609-7. [Epub ahead of print] PubMed PMID: 29956261.

5: Sasaki K, Terasaki M. Estrogen agonistic/antagonistic activity of brominated parabens. Environ Sci Pollut Res Int. 2018 Jul;25(21):21257-21266. doi: 10.1007/s11356-018-2600-3. Epub 2018 Jun 26. PubMed PMID: 29946845.

6: Gonzalez TL, Moos RK, Gersch CL, Johnson MD, Richardson RJ, Koch HM, Rae JM. Metabolites of n-Butylparaben and iso-Butylparaben Exhibit Estrogenic Properties in MCF-7 and T47D Human Breast Cancer Cell Lines. Toxicol Sci. 2018 Jul 1;164(1):50-59. doi: 10.1093/toxsci/kfy063. PubMed PMID: 29945225; PubMed Central PMCID: PMC6016648.

7: López-Ortiz CM, Sentana-Gadea I, Varó-Galvañ PJ, Maestre-Pérez SE, Prats-Rico D. Effect of magnetic ion exchange (MIEX(®)) on removal of emerging organic contaminants. Chemosphere. 2018 Oct;208:433-440. doi: 10.1016/j.chemosphere.2018.05.194. Epub 2018 Jun 1. PubMed PMID: 29885510.

8: Gomes FER, Bergo PLS, Trap MA, Spadoto M, Galinaro CA, Rodrigues-Filho E, Leitão A, Tremiliosi-Filho G. Photolysis of parabens using medium-pressure mercury lamps: Toxicity effects in MCF7, Balb/c 3T3 cells and Ceriodaphnia dubia. Chemosphere. 2018 Oct;208:325-334. doi: 10.1016/j.chemosphere.2018.05.135. Epub 2018 May 24. PubMed PMID: 29885499.

9: López-Ortiz CM, Sentana-Gadea I, Varó-Galvañ P, Maestre-Pérez SE, Prats-Rico D. The use of combined treatments for reducing parabens in surface waters: Ion-exchange resin and nanofiltration. Sci Total Environ. 2018 Oct 15;639:228-236. doi: 10.1016/j.scitotenv.2018.05.150. Epub 2018 May 19. PubMed PMID: 29787906.

10: Mijangos L, Ziarrusta H, Prieto A, Zugazua O, Zuloaga O, Olivares M, Usobiaga A, Paschke A, Etxebarria N. Evaluation of polar organic chemical integrative and hollow fibre samplers for the determination of a wide variety of organic polar compounds in seawater. Talanta. 2018 Aug 1;185:469-476. doi: 10.1016/j.talanta.2018.03.103. Epub 2018 Apr 3. PubMed PMID: 29759229.

11: Samarasinghe SVAC, Krishnan K, Naidu R, Megharaj M, Miller K, Fraser B, Aitken RJ. Parabens generate reactive oxygen species in human spermatozoa. Andrology. 2018 May 2. doi: 10.1111/andr.12499. [Epub ahead of print] PubMed PMID: 29722171.

12: Kung TA, Lee SH, Yang TC, Wang WH. Survey of selected personal care products in surface water of coral reefs in Kenting National Park, Taiwan. Sci Total Environ. 2018 Sep 1;635:1302-1307. doi: 10.1016/j.scitotenv.2018.04.115. Epub 2018 Apr 24. PubMed PMID: 29710583.

13: Makkliang F, Kanatharana P, Thavarungkul P, Thammakhet-Buranachai C. A miniaturized monolith-MWCNTs-COOH multi-stir-rod microextractor device for trace parabens determination in cosmetic and personal care products. Talanta. 2018 Jul 1;184:429-436. doi: 10.1016/j.talanta.2018.03.024. Epub 2018 Mar 14. PubMed PMID: 29674065.

14: Docea AO, Gofita E, Goumenou M, Calina D, Rogoveanu O, Varut M, Olaru C, Kerasioti E, Fountoucidou P, Taitzoglou I, Zlatian O, Rakitskii VN, Hernandez AF, Kouretas D, Tsatsakis A. Six months exposure to a real life mixture of 13 chemicals' below individual NOAELs induced non monotonic sex-dependent biochemical and redox status changes in rats. Food Chem Toxicol. 2018 May;115:470-481. doi: 10.1016/j.fct.2018.03.052. Epub 2018 Apr 3. PubMed PMID: 29621577.

15: Lu J, Li H, Tu Y, Yang Z. Biodegradation of four selected parabens with aerobic activated sludge and their transesterification product. Ecotoxicol Environ Saf. 2018 Jul 30;156:48-55. doi: 10.1016/j.ecoenv.2018.02.078. Epub 2018 Mar 9. PubMed PMID: 29529513.

16: Brown SE, Sant KE, Fleischman SM, Venezia O, Roy MA, Zhao L, Timme-Laragy AR. Pancreatic beta cells are a sensitive target of embryonic exposure to butylparaben in zebrafish (Danio rerio). Birth Defects Res. 2018 Jul 3;110(11):933-948. doi: 10.1002/bdr2.1215. Epub 2018 Mar 8. PubMed PMID: 29516647; PubMed Central PMCID: PMC6030486.

17: García-Valverde MT, Rosende M, Lucena R, Cárdenas S, Miró M. Lab-on-a-Valve Mesofluidic Platform for On-Chip Handling of Carbon-Coated Titanium Dioxide Nanotubes in a Disposable Microsolid Phase-Extraction Mode. Anal Chem. 2018 Apr 3;90(7):4783-4791. doi: 10.1021/acs.analchem.8b00158. Epub 2018 Mar 15. PubMed PMID: 29490460.

18: Messerlian C, Mustieles V, Minguez-Alarcon L, Ford JB, Calafat AM, Souter I, Williams PL, Hauser R; Environment and Reproductive Health (EARTH) Study Team. Preconception and prenatal urinary concentrations of phenols and birth size of singleton infants born to mothers and fathers from the Environment and Reproductive Health (EARTH) study. Environ Int. 2018 May;114:60-68. doi: 10.1016/j.envint.2018.02.017. Epub 2018 Feb 22. PubMed PMID: 29477955; PubMed Central PMCID: PMC5899953.

19: Pop A, Drugan T, Gutleb AC, Lupu D, Cherfan J, Loghin F, Kiss B. Estrogenic and anti-estrogenic activity of butylparaben, butylated hydroxyanisole, butylated hydroxytoluene and propyl gallate and their binary mixtures on two estrogen responsive cell lines (T47D-Kbluc, MCF-7). J Appl Toxicol. 2018 Jul;38(7):944-957. doi: 10.1002/jat.3601. Epub 2018 Feb 19. PubMed PMID: 29460325.

20: Kolatorova L, Vitku J, Hampl R, Adamcova K, Skodova T, Simkova M, Parizek A, Starka L, Duskova M. Exposure to bisphenols and parabens during pregnancy and relations to steroid changes. Environ Res. 2018 May;163:115-122. doi: 10.1016/j.envres.2018.01.031. Epub 2018 Feb 22. PubMed PMID: 29433019.