Benproperine phosphate

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 592973

CAS#: 3563-76-6

Description: Benproperine phosphate is a biochemical.


Price and Availability

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Benproperine phosphate is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 592973
Name: Benproperine phosphate
CAS#: 3563-76-6
Chemical Formula: C21H30NO5P
Exact Mass: 407.1862
Molecular Weight: 407.45
Elemental Analysis: Chemical Formula: Exact Mass: Molecular Weight: Elemental Analysis: C, 61.91; H, 7.42; N, 3.44; O, 19.63; P, 7.60


Synonym: Benproperine phosphate

IUPAC/Chemical Name: 1-(2-(2-Benzylphenoxy)-1-methylethyl)piperidinium dihydrogen phosphate

InChi Key: MCVUURBOSHQXMK-UHFFFAOYSA-N

InChi Code: InChI=1S/C21H27NO.H3O4P/c1-18(22-14-8-3-9-15-22)17-23-21-13-7-6-12-20(21)16-19-10-4-2-5-11-19;1-5(2,3)4/h2,4-7,10-13,18H,3,8-9,14-17H2,1H3;(H3,1,2,3,4)

SMILES Code: CC([NH+]1CCCCC1)COC2=CC=CC=C2CC3=CC=CC=C3.O=P(O)([O-])O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
2934.99.03.00


References

1: Wu D, Liu D, Zhang Y, Zhang Z, Li H. Unravelling the binding mechanism of benproperine with human serum albumin: A docking, fluorometric, and thermodynamic approach. Eur J Med Chem. 2018 Feb 25;146:245-250. doi: 10.1016/j.ejmech.2018.01.064. Epub 2018 Feb 4. PubMed PMID: 29407954.

2: Fang F, Qi Y, Lu F, Yang L. Highly sensitive on-site detection of drugs adulterated in botanical dietary supplements using thin layer chromatography combined with dynamic surface enhanced Raman spectroscopy. Talanta. 2016;146:351-7. doi: 10.1016/j.talanta.2015.08.067. Epub 2015 Sep 1. PubMed PMID: 26695274.

3: Feng S, Liu J, Han X, Fan J. Resonance light scattering study on the interaction of benproperine phosphate with eriochrome blue black R in the presence of sodium dodecylbenzene sulphonate and its analytical application. Luminescence. 2009 Mar-Apr;24(2):67-72. doi: 10.1002/bio.1064. PubMed PMID: 18800357.

4: Liu MY, Meng Y, Ren YL, Zhang HQ. [Nondestructive quantitative analysis of Cofrel medicines by improved partial least squares-NIR spectroscopy]. Guang Pu Xue Yu Guang Pu Fen Xi. 2007 Jun;27(6):1098-101. Chinese. PubMed PMID: 17763766.

5: Li Y, Zhong DF, Chen SW, Maeba I. Identification of some benproperine metabolites in humans and investigation of their antitussive effect. Acta Pharmacol Sin. 2005 Dec;26(12):1519-26. PubMed PMID: 16297353.

6: Li Y, Sun Y, Dong Y, Zhang Y, Zhong D. Identification and quantitative determination of benproperine metabolites in human plasma and urine by liquid chromatography-tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2006 Jan 2;830(1):71-80. Epub 2005 Nov 8. PubMed PMID: 16280263.

7: Chen S, Min L, Li Y, Li W, Zhong D, Kong W. Anti-tussive activity of benproperine enantiomers on citric-acid-induced cough in conscious guinea-pigs. J Pharm Pharmacol. 2004 Feb;56(2):277-80. PubMed PMID: 15005888.

8: Du ZM, Huang HH, Chen XY, Zhong DF. [Study on hydroxylated metabolites of benproperine in human urine]. Yao Xue Xue Bao. 2000 Dec;35(12):916-20. Chinese. PubMed PMID: 12567915.

9: Du ZM, Zhong DF, Kang Y, Chen XY. [Enantioselective pharmacokinetics of benproperine in healthy volunteers]. Yao Xue Xue Bao. 2000 Dec;35(12):909-12. Chinese. PubMed PMID: 12567913.

10: Yang XJ, Yang XY. [Determination of benproperine phosphate tablets by high performance liquid chromatography]. Se Pu. 2000 Nov;18(6):566-7. Chinese. PubMed PMID: 12541753.

11: Ida H. The nonnarcotic antitussive drug dimemorfan: a review. Clin Ther. 1997 Mar-Apr;19(2):215-31. Review. PubMed PMID: 9152562.

12: O'Connor JJ. Argon laser treatment of radiation proctitis. Arch Surg. 1989 Jun;124(6):749. PubMed PMID: 2730331.

13: Yanaura S, Kitagawa H, Hosokawa T, Misawa M. A new screening method for evaluating antitussives in conscious guinea pigs. J Pharmacobiodyn. 1982 Dec;5(12):965-71. PubMed PMID: 7169609.