Bemitradine

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 461871

CAS#: 88133-11-3

Description: Bemitradine is a diuretic antihypertensive agent.


Price and Availability

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Bemitradine is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 461871
Name: Bemitradine
CAS#: 88133-11-3
Chemical Formula: C15H17N5O
Exact Mass: 283.1433
Molecular Weight: 283.33
Elemental Analysis: C, 63.59; H, 6.05; N, 24.72; O, 5.65


Synonym: Bemitradine; Bemitradina; Bemitradinum; SC 33643; SC-33643; SC33643;

IUPAC/Chemical Name: 8-(2-ethoxyethyl)-7-phenyl-[1,2,4]triazolo[1,5-c]pyrimidin-5-amine

InChi Key: OZSPQIXKOVJJGE-UHFFFAOYSA-N

InChi Code: InChI=1S/C15H17N5O/c1-2-21-9-8-12-13(11-6-4-3-5-7-11)19-15(16)20-14(12)17-10-18-20/h3-7,10H,2,8-9H2,1H3,(H2,16,19)

SMILES Code: NC1=NC(C2=CC=CC=C2)=C(CCOCC)C3=NC=NN13


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
2934.99.03.00


References

1: Gad SC, Burton E, Chengelis CP, Levin S, Piper CE, Oshiro Y, Semler DE. Promotional activities of the non-genotoxic carcinogen bemitradine (SC-33643). J Appl Toxicol. 1992 Jun;12(3):157-64. PubMed PMID: 1629511.

2: Walls CM, Gray A, Vose CW, Robinson Y, Lopez N, Brownsill RD, Steiner JA. Disposition of bemitradine, a renal vasodilator and diuretic, in man. Xenobiotica. 1988 Dec;18(12):1413-23. PubMed PMID: 3245233.

3: Oshiro Y, Balwierz PS, Morris DL, Alden CL, Bunch RT. Morphological transformation of Syrian hamster embryo cells at pH 6.7 by bemitradine, a nongenotoxic carcinogen. In Vitr Mol Toxicol. 2001 Summer;14(2):121-7. PubMed PMID: 11690565.

4: Oshiro Y, Piper CE, Garriott ML, Balwierz PS, Soelter SG, Rohrbacher E. Genetic toxicology studies with a tumor promoter. J Appl Toxicol. 1993 Mar-Apr;13(2):91-101. PubMed PMID: 8486916.

5: Kramer JA, Curtiss SW, Kolaja KL, Alden CL, Blomme EA, Curtiss WC, Davila JC, Jackson CJ, Bunch RT. Acute molecular markers of rodent hepatic carcinogenesis identified by transcription profiling. Chem Res Toxicol. 2004 Apr;17(4):463-70. PubMed PMID: 15089088.