Talampicillin

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 592866

CAS#: 47747-56-8

Description: Talampicillin is an ester of Ampicillin. It is hydrolyzed upon absorption to release ampicillin. It is well absorbed from the gastrointestinal tract resulting in a greater bioavailability of ampicillin than can be achieved with equivalent doses of ampicillin. It is used in the treatment and prophylaxis of urinary tract infection in children.

Chemical Structure

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Talampicillin
CAS# 47747-56-8
Instruction

Theoretical Analysis

MedKoo Cat#: 592866
Name: Talampicillin
CAS#: 47747-56-8
Chemical Formula: C24H23N3O6S
Exact Mass: 481.13
Molecular Weight: 481.520
Elemental Analysis: C, 59.87; H, 4.81; N, 8.73; O, 19.94; S, 6.66

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Talampicillin

IUPAC/Chemical Name: 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 6-((aminophenylacetyl)amino)-3,3-dimethyl-7-oxo-, 1,3-dihydro-3-oxo-1-isobenzofuranyl ester, (2S-(2alpha,5alpha,6beta(S*)))-

InChi Key: SOROUYSPFADXSN-XDBZAZGESA-N

InChi Code: InChI=1S/C24H23N3O6S/c1-24(2)17(22(31)33-23-14-11-7-6-10-13(14)21(30)32-23)27-19(29)16(20(27)34-24)26-18(28)15(25)12-8-4-3-5-9-12/h3-11,15-17,20,23H,25H2,1-2H3,(H,26,28)/t15?,16-,17+,20-,23?/m1/s1

SMILES Code: O=C([C@@H](C(C)(C)S[C@]1([H])[C@@H]2NC(C(N)C3=CC=CC=C3)=O)N1C2=O)OC4OC(C5=C4C=CC=C5)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 481.52 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Smellie JM, Grüneberg RN, Bantock HM, Katz G. Talampicillin in the treatment and prophylaxis of urinary tract infection in children. Chemotherapy. 1982;28(3):218-23. PubMed PMID: 6980099.

2: Nguyen NA, Mortada LM, Notari RE. Potential improvement in the shelf life of parenterals using the prodrug approach: bacampicillin and talampicillin hydrolysis kinetics and utilization time. Pharm Res. 1988 May;5(5):288-96. PubMed PMID: 3244638.

3: Akimoto Y, Nishimura H, Komiya M, Kaneko K, Fujii A, Tamura T. Ampicillin concentrations in human dental granuloma after a single oral administration of talampicillin. Antimicrob Agents Chemother. 1988 Apr;32(4):566-7. PubMed PMID: 3377465; PubMed Central PMCID: PMC172221.