G10
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 563675

CAS#: 702662-50-8

Description: G10 is a human-specific STING agonist, triggering IRF3/IFN-associated transcription in human fibroblasts.


Price and Availability

Size
Price

1mg
USD 210
Size
Price

5mg
USD 400
Size
Price

10mg
USD 650

G10, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 563675
Name: G10
CAS#: 702662-50-8
Chemical Formula: C21H16ClFN2O3S
Exact Mass: 430.0554
Molecular Weight: 430.87
Elemental Analysis: C, 58.54; H, 3.74; Cl, 8.23; F, 4.41; N, 6.50; O, 11.14; S, 7.44


Synonym: G10; G-10; G 10; STING agonist G10;

IUPAC/Chemical Name: 4-(2-Chloro-6-fluorobenzyl)-N-(furan-2-ylmethyl)-3-oxo-3,4-dihydro-2H-benzo[b][1,4]thiazine-6-carboxamide

InChi Key: NAGKYJATVFXZKN-UHFFFAOYSA-N

InChi Code: InChI=1S/C21H16ClFN2O3S/c22-16-4-1-5-17(23)15(16)11-25-18-9-13(6-7-19(18)29-12-20(25)26)21(27)24-10-14-3-2-8-28-14/h1-9H,10-12H2,(H,24,27)

SMILES Code: O=C(C1=CC=C(C(N2CC3=C(F)C=CC=C3Cl)=C1)SCC2=O)NCC4=CC=CO4


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
2934.99.03.00


References

1: Sali TM, Pryke KM, Abraham J, Liu A, Archer I, Broeckel R, Staverosky JA, Smith JL, Al-Shammari A, Amsler L, Sheridan K, Nilsen A, Streblow DN, DeFilippis VR. Characterization of a Novel Human-Specific STING Agonist that Elicits Antiviral Activity Against Emerging Alphaviruses. PLoS Pathog. 2015 Dec 8;11(12):e1005324. doi: 10.1371/journal.ppat.1005324. eCollection 2015 Dec. PubMed PMID: 26646986; PubMed Central PMCID: PMC4672893.