WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 599228

CAS#: 165739-83-3

Description: 4-Chloroloratadine is an impurity of Loratadine.

Chemical Structure

CAS# 165739-83-3

Theoretical Analysis

MedKoo Cat#: 599228
Name: 4-Chloroloratadine
CAS#: 165739-83-3
Chemical Formula: C22H22Cl2N2O2
Exact Mass: 416.1058
Molecular Weight: 417.33
Elemental Analysis: C, 63.32; H, 5.31; Cl, 16.99; N, 6.71; O, 7.67

Price and Availability

Size Price Availability Quantity
1.0mg USD 400.0 2 Weeks
100.0mg USD 2090.0 2 Weeks
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Synonym: 4-Chloroloratadine; 4-Chloro loratadine; Loratadine specified impurity C;

IUPAC/Chemical Name: ethyl 4-(4,8-dichloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)piperidine-1-carboxylate


InChi Code: InChI=1S/C22H22Cl2N2O2/c1-2-28-22(27)26-11-8-14(9-12-26)20-17-6-4-16(23)13-15(17)3-5-18-19(24)7-10-25-21(18)20/h4,6-7,10,13H,2-3,5,8-9,11-12H2,1H3


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

Preparing Stock Solutions

The following data is based on the product molecular weight 417.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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9: Villani FJ, Magatti CV, Vashi DB, Wong J, Popper TL. N-substituted 11-(4-piperidylene)-5,6-dihydro-11H-benzo-[5,6]cyclohepta [1,2-b]pyridines. Antihistamines with no sedating liability. Arzneimittelforschung. 1986 Sep;36(9):1311-4. PubMed PMID: 2947582.

10: Kaminski JJ, Carruthers NI, Wong SC, Chan TM, Billah MM, Tozzi S, McPhail AT. Conformational considerations in the design of dual antagonists of platelet-activating factor (PAF) and histamine. Bioorg Med Chem. 1999 Jul;7(7):1413-23. PubMed PMID: 10465415.

11: Barnett A, Iorio LC, Kreutner W, Tozzi S, Ahn HS, Gulbenkian A. Evaluation of the CNS properties of SCH 29851, a potential non-sedating antihistamine. Agents Actions. 1984 Jun;14(5-6):590-7. PubMed PMID: 6236679.

12: Merlos M, Giral M, Balsa D, Ferrando R, Queralt M, Puigdemont A, García-Rafanell J, Forn J. Rupatadine, a new potent, orally active dual antagonist of histamine and platelet-activating factor (PAF). J Pharmacol Exp Ther. 1997 Jan;280(1):114-21. PubMed PMID: 8996188.