Becanthone HCl

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MedKoo CAT#: 599221

CAS#: 5591-22-0

Description: Becanthone HCl is an antischistosomal agent.


Price and Availability

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Pricing updated 2020-08-15. Prices are subject to change without notice.

Becanthone HCl is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 599221
Name: Becanthone HCl
CAS#: 5591-22-0
Chemical Formula: C22H29ClN2O3S
Exact Mass:
Molecular Weight: 436.99
Elemental Analysis: C, 60.47; H, 6.69; Cl, 8.11; N, 6.41; O, 10.98; S, 7.34


Synonym: Becanthone hydrochloride; Becanthone HCl; NSC 15796; NSC-15796; NSC15796; Win 13820; Loranil;

IUPAC/Chemical Name: 1-((2-(ethyl(2-hydroxy-2-methoxypropyl)amino)ethyl)amino)-4-methyl-9H-thioxanthen-9-one hydrochloride

InChi Key: PMQCOTFQAYYUME-UHFFFAOYSA-N

InChi Code: InChI=1S/C22H28N2O3S.ClH/c1-5-24(14-22(3,26)27-4)13-12-23-17-11-10-15(2)21-19(17)20(25)16-8-6-7-9-18(16)28-21;/h6-11,23,26H,5,12-14H2,1-4H3;1H

SMILES Code: O=C1C2=C(SC3=C1C=CC=C3)C(C)=CC=C2NCCN(CC)CC(OC)(O)C.[H]Cl


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.03.00


References

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2: Guo L, Huang K, Guo R, He AQ, Weng SF, Yang ZL, Zhao Y, Xia JM, Xu YZ, Kang TG, Wu JG. [On the Tributylphosphate-Based Super-Concentrated HCl System]. Guang Pu Xue Yu Guang Pu Fen Xi. 2015 Aug;35(8):2241-5. Chinese. PubMed PMID: 26672302.

3: Hidalgo-Mazzei D, Mateu A, Undurraga J, Rosa AR, Pacchiarotti I, Bonnin Cdel M, Sánchez-Moreno J, Colom F, Vieta E. e-HCL-32: a useful, valid and user friendly tool in the screening of bipolar II disorder. Compr Psychiatry. 2015 Jan;56:283-8. doi: 10.1016/j.comppsych.2014.09.008. Epub 2014 Sep 6. PubMed PMID: 25261889.

4: Zhang H, Yang X, Li C, Shang S, Wang J. Effects of minocycline-HCl paste root conditioning on periodontal surgery: in vitro and in vivo studies. Int J Clin Exp Med. 2015 Mar 15;8(3):4080-6. eCollection 2015. PubMed PMID: 26064313; PubMed Central PMCID: PMC4443147.

5: Guo R, Guo L, Huang K, He A, Zhang J, Zheng L, Liu Y, Kang T, Gao X, Weng S, Zhao Y, Yang Z, Xu Y, Noda I, Wu J. Investigation on the trioctylphosphine oxide-based super-concentrated HCl system. Spectrochim Acta A Mol Biomol Spectrosc. 2015 Feb 5;136 Pt B:288-94. doi: 10.1016/j.saa.2014.08.133. Epub 2014 Oct 5. PubMed PMID: 25448932.

6: Pettirossi V, Santi A, Imperi E, Russo G, Pucciarini A, Bigerna B, Schiavoni G, Fortini E, Spanhol-Rosseto A, Sportoletti P, Mannucci R, Martelli MP, Klein-Hitpass L, Falini B, Tiacci E. BRAF inhibitors reverse the unique molecular signature and phenotype of hairy cell leukemia and exert potent antileukemic activity. Blood. 2015 Feb 19;125(8):1207-16. doi: 10.1182/blood-2014-10-603100. Epub 2014 Dec 5. PubMed PMID: 25480661; PubMed Central PMCID: PMC4366655.

7: Moradi CP, Douberly GE. Infrared Laser Spectroscopy of the L-Shaped Cl-HCl Complex Formed in Superfluid (4)He Nanodroplets. J Phys Chem A. 2015 Dec 17;119(50):12028-35. doi: 10.1021/acs.jpca.5b04449. Epub 2015 Jul 8. PubMed PMID: 26114768.

8: Sagdinc SG, Erdas D, Gunduz I, Sahinturk AE. FT-IR and FT-Raman spectra, molecular structure and first-order molecular hyperpolarizabilities of a potential antihistaminic drug, cyproheptadine HCl. Spectrochim Acta A Mol Biomol Spectrosc. 2015 Jan 5;134:350-60. doi: 10.1016/j.saa.2014.06.109. Epub 2014 Jun 26. PubMed PMID: 25022508.

9: Meyer TD, Schrader J, Ridley M, Lex C. The Hypomania Checklist (HCL) - systematic review of its properties to screen for bipolar disorders. Compr Psychiatry. 2014 Jul;55(5):1310-21. doi: 10.1016/j.comppsych.2014.03.002. Epub 2014 Mar 21. Review. PubMed PMID: 24746530.

10: Feng Y, Xiang YT, Huang W, Wang G, Feng L, Tian TF, Geng Y, Ungvari GS, Chiu HFK, Tse AWY, Angst J. The 33-item Hypomania Checklist (HCL-33): A new self-completed screening instrument for bipolar disorder. J Affect Disord. 2016 Jan 15;190:214-220. doi: 10.1016/j.jad.2015.09.057. Epub 2015 Oct 24. PubMed PMID: 26519642.

11: Bassani AS, Banov D. Evaluation of the Percutaneous Absorption of Ketamine HCl, Gabapentin, Clonidine HCl, and Baclofen, in Compounded Transdermal Pain Formulations, Using the Franz Finite Dose Model. Pain Med. 2016 Feb;17(2):230-8. PubMed PMID: 26352507.

12: Jain P, Pemmaraju N, Ravandi F. Update on the biology and treatment options for hairy cell leukemia. Curr Treat Options Oncol. 2014 Jun;15(2):187-209. doi: 10.1007/s11864-014-0285-5. Review. PubMed PMID: 24652320; PubMed Central PMCID: PMC4198068.

13: Łojko D, Dudek D, Angst J, Siwek M, Michalak M, Rybakowski J. The 33-item Hypomania Checklist (HCL-33) - a study of the consistency between self - and external assessments in Polish bipolar patients. Psychiatr Pol. 2016 Dec 23;50(6):1085-1092. doi: 10.12740/PP/66358. English, Polish. PubMed PMID: 28211548.

14: Jacobsson D, Lehmann S, Dick KA. Crystal structure tuning in GaAs nanowires using HCl. Nanoscale. 2014 Jul 21;6(14):8257-64. doi: 10.1039/c4nr00991f. PubMed PMID: 24931099.

15: Lique F. Communication: Rotational excitation of HCl by H: Rigid rotor vs. reactive approaches. J Chem Phys. 2015 Jun 28;142(24):241102. doi: 10.1063/1.4922987. PubMed PMID: 26133402.

16: Brown TM, Nestler MJ, Rossabi SM, Heard GL, Setser DW, Holmes BE. Characterization of the 1,1-HCl Elimination Reaction of Vibrationally Excited CD3CHFCl Molecules and Assignment of Threshold Energies for 1,1-HCl and 1,2-DCl plus 1,1-HF and 1,2-DF Elimination Reactions. J Phys Chem A. 2015 Sep 10;119(36):9441-51. doi: 10.1021/acs.jpca.5b06638. Epub 2015 Sep 1. PubMed PMID: 26291380.

17: Lee K, Oh H, Lee EH, Kim JH, Kim JH, Hong KS. Investigation of the clinical utility of the hypomania checklist 32 (HCL-32) for the screening of bipolar disorders in the non-clinical adult population. BMC Psychiatry. 2016 May 4;16:124. doi: 10.1186/s12888-016-0831-8. PubMed PMID: 27146281; PubMed Central PMCID: PMC4855804.

18: Huang X, Liu W, Feng B, Tan Q, Ji J. Applicability of the Chinese version of the Hypomania Symptom Checklist (HCL-32) scale for outpatients of psychiatric departments in general hospitals. PLoS One. 2013 Oct 7;8(10):e75631. doi: 10.1371/journal.pone.0075631. eCollection 2013. PubMed PMID: 24116062; PubMed Central PMCID: PMC3792138.

19: Burger JA. BRAF mutation: supporting diversity in HCL. Blood. 2012 Apr 5;119(14):3193-4. doi: 10.1182/blood-2012-01-403659. PubMed PMID: 22493212.

20: Borovinskaya M, Robert B, Plakogiannis FM. Evaluation of in vitro percutaneous absorption of olanzapine and fluoxetine HCl: enhancement properties of olanzapine. Drug Dev Ind Pharm. 2012 Feb;38(2):227-34. doi: 10.3109/03639045.2011.597765. Epub 2011 Aug 24. Review. PubMed PMID: 21864096.