X 14868A

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 599197

CAS#: 79356-08-4

Description: X 14868A, also known as Maduramicin, is a natural polyether ionophore antibiotic first isolated from the actinomycete Actinomadura rubra. It is cytotoxic against Cryptosporidium spp. and is commonly used in veterinary medicine as an anti-coccidial agent. Maduramicin is also cytotoxic against Plasmodium gametocytes and potentiates the gametocytocidal activity of the pyrazoleamide PA21A050.

Chemical Structure

X 14868A
CAS# 79356-08-4

Theoretical Analysis

MedKoo Cat#: 599197
Name: X 14868A
CAS#: 79356-08-4
Chemical Formula: C47H80O17
Exact Mass: 916.5396
Molecular Weight: 917.14
Elemental Analysis: C, 61.55; H, 8.79; O, 29.66

Price and Availability

Size Price Availability Quantity
5.0mg USD 360.0 2 Weeks
25.0mg USD 960.0 2 Weeks
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Synonym: X 14868A; X-14868A; X14868A;

IUPAC/Chemical Name: 2-((2S,3S,4S,5R,6S)-6-((R)-1-((2R,5R,7S,8R,9S)-2-((2S,2'R,3'S,5R,5'S)-3'-(((2R,4S,5S,6S)-4,5-dimethoxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-5'-((2S,3S,5R,6S)-6-hydroxy-3,5,6-trimethyltetrahydro-2H-pyran-2-yl)-2-methyloctahydro-[2,2'-bifuran]-5-yl)-9-hydroxy-2,8-dimethyl-1,6-dioxaspiro[4.5]decan-7-yl)ethyl)-2-hydroxy-4,5-dimethoxy-3-methyltetrahydro-2H-pyran-2-yl)acetic acid


InChi Code: InChI=1S/C47H80O17/c1-23-18-24(2)45(9,51)61-36(23)31-19-32(58-35-20-30(53-10)40(55-12)28(6)57-35)42(59-31)44(8)15-14-33(60-44)43(7)16-17-46(64-43)21-29(48)25(3)37(62-46)26(4)38-41(56-13)39(54-11)27(5)47(52,63-38)22-34(49)50/h23-33,35-42,48,51-52H,14-22H2,1-13H3,(H,49,50)/t23-,24+,25+,26+,27-,28-,29-,30-,31-,32-,33+,35+,36-,37-,38-,39-,40-,41-,42+,43+,44-,45-,46+,47-/m0/s1

SMILES Code: O=C(O)C[C@]([C@H]1C)(O)O[C@@H]([C@@H]([C@@H]2[C@H](C)[C@@H](O)C[C@]3(CC[C@@]([C@@H]4O[C@@](C)(CC4)[C@H]5[C@H](C[C@H](O5)[C@@H]6[C@@H](C)C[C@@H](C)[C@](O)(C)O6)O[C@H]7O[C@@H](C)[C@H](OC)[C@@H](OC)C7)(C)O3)O2)C)[C@H](OC)[C@H]1OC

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

Preparing Stock Solutions

The following data is based on the product molecular weight 917.14 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Liu CM, Hermann TE, Downey A, Prosser BL, Schildknecht E, Palleroni NJ, Westley JW, Miller PA. Novel polyether antibiotics X-14868A, B, C, and D produced by a Nocardia. Discovery, fermentation, biological as well as ionophore properties and taxonomy of the producing culture. J Antibiot (Tokyo). 1983 Apr;36(4):343-50. PubMed PMID: 6853364.