X 14868A
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 599197

CAS#: 79356-08-4

Description: X 14868A, also known as Maduramicin, is a natural polyether ionophore antibiotic first isolated from the actinomycete Actinomadura rubra. It is cytotoxic against Cryptosporidium spp. and is commonly used in veterinary medicine as an anti-coccidial agent. Maduramicin is also cytotoxic against Plasmodium gametocytes and potentiates the gametocytocidal activity of the pyrazoleamide PA21A050.


Price and Availability

Size
Price

5mg
USD 360
Size
Price

25mg
USD 960
Size
Price

X 14868A purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 599197
Name: X 14868A
CAS#: 79356-08-4
Chemical Formula: C47H80O17
Exact Mass: 916.5396
Molecular Weight: 917.14
Elemental Analysis: C, 61.55; H, 8.79; O, 29.66


Synonym: X 14868A; X-14868A; X14868A;

IUPAC/Chemical Name: 2-((2S,3S,4S,5R,6S)-6-((R)-1-((2R,5R,7S,8R,9S)-2-((2S,2'R,3'S,5R,5'S)-3'-(((2R,4S,5S,6S)-4,5-dimethoxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-5'-((2S,3S,5R,6S)-6-hydroxy-3,5,6-trimethyltetrahydro-2H-pyran-2-yl)-2-methyloctahydro-[2,2'-bifuran]-5-yl)-9-hydroxy-2,8-dimethyl-1,6-dioxaspiro[4.5]decan-7-yl)ethyl)-2-hydroxy-4,5-dimethoxy-3-methyltetrahydro-2H-pyran-2-yl)acetic acid

InChi Key: RWVUEZAROXKXRT-YBHBXVTESA-N

InChi Code: InChI=1S/C47H80O17/c1-23-18-24(2)45(9,51)61-36(23)31-19-32(58-35-20-30(53-10)40(55-12)28(6)57-35)42(59-31)44(8)15-14-33(60-44)43(7)16-17-46(64-43)21-29(48)25(3)37(62-46)26(4)38-41(56-13)39(54-11)27(5)47(52,63-38)22-34(49)50/h23-33,35-42,48,51-52H,14-22H2,1-13H3,(H,49,50)/t23-,24+,25+,26+,27-,28-,29-,30-,31-,32-,33+,35+,36-,37-,38-,39-,40-,41-,42+,43+,44-,45-,46+,47-/m0/s1

SMILES Code: O=C(O)C[C@]([C@H]1C)(O)O[C@@H]([C@@H]([C@@H]2[C@H](C)[C@@H](O)C[C@]3(CC[C@@]([C@@H]4O[C@@](C)(CC4)[C@H]5[C@H](C[C@H](O5)[C@@H]6[C@@H](C)C[C@@H](C)[C@](O)(C)O6)O[C@H]7O[C@@H](C)[C@H](OC)[C@@H](OC)C7)(C)O3)O2)C)[C@H](OC)[C@H]1OC


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
2934.99.03.00


References

1: Liu CM, Hermann TE, Downey A, Prosser BL, Schildknecht E, Palleroni NJ, Westley JW, Miller PA. Novel polyether antibiotics X-14868A, B, C, and D produced by a Nocardia. Discovery, fermentation, biological as well as ionophore properties and taxonomy of the producing culture. J Antibiot (Tokyo). 1983 Apr;36(4):343-50. PubMed PMID: 6853364.