Quinfamide

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 592793

CAS#: 62265-68-3

Description: Quinfamide is used in the treatment of chronic amebiasis in pediatric patients.

Chemical Structure

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Quinfamide
CAS# 62265-68-3
Product data Instruction

Theoretical Analysis

MedKoo Cat#: 592793
Name: Quinfamide
CAS#: 62265-68-3
Chemical Formula: C16H13Cl2NO4
Exact Mass: 353.02
Molecular Weight: 354.180
Elemental Analysis: C, 54.26; H, 3.70; Cl, 20.02; N, 3.95; O, 18.07

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Quinfamide; Quinfamido

IUPAC/Chemical Name: 2-Furancarboxylic acid, 1-(dichloroacetyl)-1,2,3,4-tetrahydro-6-quinolinyl ester

InChi Key: SBJGFIXQRZOVTO-UHFFFAOYSA-N

InChi Code: InChI=1S/C16H13Cl2NO4/c17-14(18)15(20)19-7-1-3-10-9-11(5-6-12(10)19)23-16(21)13-4-2-8-22-13/h2,4-6,8-9,14H,1,3,7H2

SMILES Code: O=C(C1=CC=CO1)OC2=CC3=C(N(C(C(Cl)Cl)=O)CCC3)C=C2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Product Data:
Product Data
Instruction:
View handling instruction
Biological target: Quinafimide is an investigational compound that has been used in trials for the treatment of Amoebiasis and Helminthiasis. The details of the mechanism of action are not known, but the overall effect is intraluminal immobilization of the Entamoeba.
In vitro activity: The susceptibility of a strain of Giardia lamblia to benzimidazole carbamates, 5-nitroimidazoles, nitrofurans and other drugs was studied in vitro. Quinfamide did not inhibit the growth of the parasite at a concentration of 200 mg/L. Reference: Clin Drug Investig. 2000;20(2):89-93. https://pubmed.ncbi.nlm.nih.gov/1518040/
In vivo activity: In this study, 3 groups underwent quinfamide treatment. Group 1 had patients that had three CPS analyses after 12 months; Group 2 had CPS analyses at months 3, 6, 9, and 12; and Group 3 had three CPS analyses at months 6 and 12. Group 1 had 37.6% of subjects still testing positive for Entamoeba histolytica cysts in stool samples; of Group 2, 12.5%; and Group 3, 23.5%. This study showed that antiamoebic chemoprophylaxis can be used for amoebic infection treatment when personal hygiene and diet are not improved. Reference: ScientificWorldJournal. 2002 Apr 20;2:1070-8. https://pubmed.ncbi.nlm.nih.gov/12805964/

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 3.5 10.00

Preparing Stock Solutions

The following data is based on the product molecular weight 354.18 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol: 1. Naguib IA, Hassan ES, Emam AA, Abdelaleem EA. Development and Validation of HPTLC and Green HPLC Methods for Determination of a New Combination of Quinfamide and Mebendazole. J Chromatogr Sci. 2019 Dec 19;58(1):16-21. doi: 10.1093/chromsci/bmz100. PMID: 31879753. 2. Cedillo-Rivera R, Muñoz O. In-vitro susceptibility of Giardia lamblia to albendazole, mebendazole and other chemotherapeutic agents. J Med Microbiol. 1992 Sep;37(3):221-4. doi: 10.1099/00222615-37-3-221. PMID: 1518040. 3. Padilla N, Diaz R, Alarcon A, Barreda R. Antiamoebic chemoprophylaxis using quinfamide in children: a comparative study. ScientificWorldJournal. 2002 Apr 20;2:1070-8. doi: 10.1100/tsw.2002.174. PMID: 12805964; PMCID: PMC6009339. 4. Padilla N, Díaz R, Muñoz M. Efficacy and Safety of Quinfamide versus Secnidazole in the Management of Amoebic Non-Dysenteric Colitis in Children. Clin Drug Investig. 2000;20(2):89-93. doi: 10.2165/00044011-200020020-00003. PMID: 23315350.
In vitro protocol: 1. Naguib IA, Hassan ES, Emam AA, Abdelaleem EA. Development and Validation of HPTLC and Green HPLC Methods for Determination of a New Combination of Quinfamide and Mebendazole. J Chromatogr Sci. 2019 Dec 19;58(1):16-21. doi: 10.1093/chromsci/bmz100. PMID: 31879753. 2. Cedillo-Rivera R, Muñoz O. In-vitro susceptibility of Giardia lamblia to albendazole, mebendazole and other chemotherapeutic agents. J Med Microbiol. 1992 Sep;37(3):221-4. doi: 10.1099/00222615-37-3-221. PMID: 1518040.
In vivo protocol: 1. Padilla N, Diaz R, Alarcon A, Barreda R. Antiamoebic chemoprophylaxis using quinfamide in children: a comparative study. ScientificWorldJournal. 2002 Apr 20;2:1070-8. doi: 10.1100/tsw.2002.174. PMID: 12805964; PMCID: PMC6009339. 2. Padilla N, Díaz R, Muñoz M. Efficacy and Safety of Quinfamide versus Secnidazole in the Management of Amoebic Non-Dysenteric Colitis in Children. Clin Drug Investig. 2000;20(2):89-93. doi: 10.2165/00044011-200020020-00003. PMID: 23315350.

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1. Naguib IA, Hassan ES, Emam AA, Abdelaleem EA. Development and Validation of HPTLC and Green HPLC Methods for Determination of a New Combination of Quinfamide and Mebendazole. J Chromatogr Sci. 2019 Dec 19;58(1):16-21. doi:10.1093/chromsci/bmz100. PMID: 31879753.
2. Cedillo-Rivera R, Muñoz O. In-vitro susceptibility of Giardia lamblia to albendazole, mebendazole and other chemotherapeutic agents. J Med Microbiol. 1992 Sep;37(3):221-4. doi: 10.1099/00222615-37-3-221. PMID: 1518040.
3. Padilla N, Diaz R, Alarcon A, Barreda R. Antiamoebic chemoprophylaxis using quinfamide in children: a comparative study. ScientificWorldJournal. 2002 Apr 20;2:1070-8. doi: 10.1100/tsw.2002.174. PMID: 12805964; PMCID: PMC6009339.
4. Padilla N, Díaz R, Muñoz M. Efficacy and Safety of Quinfamide versus Secnidazole in the Management of Amoebic NonDysenteric Colitis in Children. Clin Drug Investig. 2000;20(2):89-93. doi: 10.2165/00044011-200020020-00003. PMID:
23315350.