MedKoo Biosciences

TP2
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 563639

CAS#: 420089-51-6

Description: TP2 is an inhibitor of polyketide synthase 13 (Pks13), preventing synthesis of mycolic acid and resulting in mycobacterial cell death.

Chemical Structure

TP2

CAS# 420089-51-6

Instruction

Theoretical Analysis

MedKoo Cat#: 563639
Name: TP2
CAS#: 420089-51-6
Chemical Formula: C18H14F5NO3S
Exact Mass: 419.06
Molecular Weight: 419.360
Elemental Analysis: C, 51.55; H, 3.37; F, 22.65; N, 3.34; O, 11.45; S, 7.64

Price and Availability

Size	Price	Availability	Quantity
5mg	USD 270
25mg	USD 650
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: TP2; TP-2; TP 2; Thiophene-2; Thiophene 2;

IUPAC/Chemical Name: 5,6,7,8-Tetrahydro-2-[(2,3,4,5,6-pentafluorobenzoyl)amino]-4H-cyclohepta[b]thiophene-3-carboxylic acid methyl ester

InChi Key: AVRWEULSKHQETA-UHFFFAOYSA-N

InChi Code: InChI=1S/C18H14F5NO3S/c1-27-18(26)9-7-5-3-2-4-6-8(7)28-17(9)24-16(25)10-11(19)13(21)15(23)14(22)12(10)20/h2-6H2,1H3,(H,24,25)

SMILES Code: O=C(C1=C(NC(C2=C(F)C(F)=C(F)C(F)=C2F)=O)SC3=C1CCCCC3)OC

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 419.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

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7: Strobl LJ, Höfelmayr H, Stein C, Marschall G, Brielmeier M, Laux G, Bornkamm GW, Zimber-Strobl U. Both Epstein-Barr viral nuclear antigen 2 (EBNA2) and activated Notch1 transactivate genes by interacting with the cellular protein RBP-J kappa. Immunobiology. 1997 Dec;198(1-3):299-306. Review. PubMed PMID: 9442401.

8: González Enguita C, Caro Cebrián C, Sánz Vélez JI, Gil Sánz MJ, Martínez Bengoechea J, Urruchi Fernández P, Rioja Sánz LA. [Non-radical treatment and bladder conservation in infiltrating tumor of the bladder]. Actas Urol Esp. 1992 Mar;16(3):240-6. Review. Spanish. PubMed PMID: 1621550.

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TP2 featured