pythiDC
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MedKoo CAT#: 563631

CAS#: 1821370-71-1

Description: PythiDC is a selective inhibitor of collagen prolyl 4-hydroxylase, neither causing general toxicity nor disrupting iron homeostasis.


Chemical Structure

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pythiDC
CAS# 1821370-71-1

Theoretical Analysis

MedKoo Cat#: 563631
Name: pythiDC
CAS#: 1821370-71-1
Chemical Formula: C10H6N2O4S
Exact Mass: 250.00
Molecular Weight: 250.230
Elemental Analysis: C, 48.00; H, 2.42; N, 11.20; O, 25.58; S, 12.81

Price and Availability

Size Price Availability Quantity
5mg USD 150 Ready to Ship
10mg USD 250 Ready to ship
25mg USD 450 Ready to Ship
100mg USD 750 Ready to Ship
200mg USD 1250 Ready to ship
1g USD 4250 Ready to ship
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Synonym: pythiDC; pythi-DC; pythi DC;

IUPAC/Chemical Name: 2-(5-Carboxythiazol-2-yl)pyridine-5-carboxylic acid

InChi Key: ISYUGJYTQIZJHV-UHFFFAOYSA-N

InChi Code: InChI=1S/C10H6N2O4S/c13-9(14)5-1-2-6(11-3-5)8-12-4-7(17-8)10(15)16/h1-4H,(H,13,14)(H,15,16)

SMILES Code: O=C(C1=CN=C(C2=NC=C(C(O)=O)S2)C=C1)O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target: PythiDC is a selective collagen prolyl 4-hydroxylase (CP4H1) inhibitor with an IC50 value of 4.0 μM.
In vitro activity: PythiDC decreased the malignant phenotypes of lung cancer cell lines in vitro. Reference: Transl Oncol. 2021 Aug;14(8):101128. https://pubmed.ncbi.nlm.nih.gov/34049151/
In vivo activity: PythiDC treatment of colorectal cancer patient-derived xenografts that exhibited high expression of P4HA1 resulted in tumor regression. P4HA1 contributes to colorectal cancer progression and metastasis and that targeting P4HA1 with pythiDC could be an effective therapeutic strategy for aggressive colorectal cancers. Reference: Transl Oncol. 2020 Apr;13(4):100754. https://pubmed.ncbi.nlm.nih.gov/32199274/

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 4.9 19.58

Preparing Stock Solutions

The following data is based on the product molecular weight 250.23 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol: 1. Robinson AD, Chakravarthi BVSK, Agarwal S, Chandrashekar DS, Davenport ML, Chen G, Manne U, Beer DG, Edmonds MD, Varambally S. Collagen modifying enzyme P4HA1 is overexpressed and plays a role in lung adenocarcinoma. Transl Oncol. 2021 Aug;14(8):101128. doi: 10.1016/j.tranon.2021.101128. Epub 2021 May 25. PMID: 34049151; PMCID: PMC8170159. 2. Agarwal S, Behring M, Kim HG, Bajpai P, Chakravarthi BVSK, Gupta N, Elkholy A, Al Diffalha S, Varambally S, Manne U. Targeting P4HA1 with a Small Molecule Inhibitor in a Colorectal Cancer PDX Model. Transl Oncol. 2020 Apr;13(4):100754. doi: 10.1016/j.tranon.2020.100754. Epub 2020 Mar 18. Erratum in: Transl Oncol. 2021 Nov;14(11):101142. PMID: 32199274; PMCID: PMC7082635.
In vitro protocol: 1. Robinson AD, Chakravarthi BVSK, Agarwal S, Chandrashekar DS, Davenport ML, Chen G, Manne U, Beer DG, Edmonds MD, Varambally S. Collagen modifying enzyme P4HA1 is overexpressed and plays a role in lung adenocarcinoma. Transl Oncol. 2021 Aug;14(8):101128. doi: 10.1016/j.tranon.2021.101128. Epub 2021 May 25. PMID: 34049151; PMCID: PMC8170159.
In vivo protocol: 1. Agarwal S, Behring M, Kim HG, Bajpai P, Chakravarthi BVSK, Gupta N, Elkholy A, Al Diffalha S, Varambally S, Manne U. Targeting P4HA1 with a Small Molecule Inhibitor in a Colorectal Cancer PDX Model. Transl Oncol. 2020 Apr;13(4):100754. doi: 10.1016/j.tranon.2020.100754. Epub 2020 Mar 18. Erratum in: Transl Oncol. 2021 Nov;14(11):101142. PMID: 32199274; PMCID: PMC7082635.

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