Broparestrol (E)-

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 599113

CAS#: 22393-62-0

Description: Broparestrol (E)- is a synthetic, nonsteroidal selective estrogen receptor modulator (SERM) of the triphenylethylene group that has been used in Europe as a dermatological agent and for the treatment of breast cancer.

Chemical Structure

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Broparestrol (E)-
CAS# 22393-62-0
Instruction

Theoretical Analysis

MedKoo Cat#: 599113
Name: Broparestrol (E)-
CAS#: 22393-62-0
Chemical Formula: C22H19Br
Exact Mass: 362.07
Molecular Weight: 363.290
Elemental Analysis: C, 72.73; H, 5.27; Br, 21.99

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Broparestrol (E)-; LN 1643; LN-1643; LN1643; trans-Broparestrol;

IUPAC/Chemical Name: (E)-(1-bromo-2-(4-ethylphenyl)ethene-1,2-diyl)dibenzene

InChi Key: OQCYTSHIQNPJIC-QURGRASLSA-N

InChi Code: InChI=1S/C22H19Br/c1-2-17-13-15-19(16-14-17)21(18-9-5-3-6-10-18)22(23)20-11-7-4-8-12-20/h3-16H,2H2,1H3/b22-21+

SMILES Code: CCC1=CC=C(/C(C2=CC=CC=C2)=C(Br)\C3=CC=CC=C3)C=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 363.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Rodier PN, Ceolin R, Dubois P, Fournival JL. [(Z)-broparestrol]. Acta Crystallogr C. 1989 Sep 15;45 ( Pt 9):1455-7. French. PubMed PMID: 2604956.

2: Rudali G, Rendon AM, Guggiari M. [Inhibition of mammary carcinogenesis of C3H/f mice with broparestrol]. C R Seances Soc Biol Fil. 1978;172(5):845-9. French. PubMed PMID: 157196.

3: Syed N, Langer J, Janczar K, Singh P, Lo Nigro C, Lattanzio L, Coley HM, Hatzimichael E, Bomalaski J, Szlosarek P, Awad M, O'Neil K, Roncaroli F, Crook T. Epigenetic status of argininosuccinate synthetase and argininosuccinate lyase modulates autophagy and cell death in glioblastoma. Cell Death Dis. 2013 Jan 17;4:e458. doi: 10.1038/cddis.2012.197. PubMed PMID: 23328665; PubMed Central PMCID: PMC3563985.

4: Edery M, Goussard J, Vives C, Rudali G, Drosdowsky MA. Interactions between prolactin and ovarian secretions during mammary tumorigenesis in the mouse. Biomedicine. 1980 Dec;33(8):265-7. PubMed PMID: 7213925.

5: Drosdowsky M, Edery M, Guggiari M, Montes-Rendon A, Rudali G, Vives C. Inhibition of prolactin-induced mammary cancer in C3Hf (XVII) mice with the trans isomer of bromotriphenylethylene. Cancer Res. 1980 May;40(5):1674-9. PubMed PMID: 6245799.

6: Edery M, Barnova A, Drosdowsky M, Guggiari M, Vives C, Rudali G. Isomers of broparoestrol and antiestrogen action: comparison with tamoxifen. Biomed Pharmacother. 1985;39(6):326-30. PubMed PMID: 4084664.

7: Borgna JL, Coezy E, Rochefort H. Mode of action of LN 1643 (a triphenylbromoethylene antiestrogen): probable mediation by the estrogen receptor and high affinity metabolite. Biochem Pharmacol. 1982 Oct 15;31(20):3187-91. PubMed PMID: 7150347.