QCM 00860
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 572300

CAS#: 2107273-64-1

Description: QCM 00860, also known as N-methyl-N'-methyl-O-(m-PEG4)-O'-(azide-PEG4)-Cy3 is a PEG derivative containing cyanine dye with excitation/emission maximum 555/570 nm as well as an azide group, which enables Click Chemistry. The hydophilic PEG spacer increases solubility in aqueous media. This product has no formal name at the moment. For the convenience of communication, a temporary code name was therefore proposed according to MedKoo Chemical Nomenclature (see web page: https://www.medkoo.com/page/naming).


Chemical Structure

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QCM 00860
CAS# 2107273-64-1

Theoretical Analysis

MedKoo Cat#: 572300
Name: QCM 00860
CAS#: 2107273-64-1
Chemical Formula: C44H66ClN5O10
Exact Mass: 859.45
Molecular Weight: 860.490
Elemental Analysis: C, 61.42; H, 7.73; Cl, 4.12; N, 8.14; O, 18.59

Price and Availability

Size Price Availability Quantity
1mg USD 400
2mg USD 640
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Synonym: N-methyl-N'-methyl-O-(m-PEG4)-O'-(azide-PEG4)-Cy3; QCM 00860; QCM-00860; QCM00860

IUPAC/Chemical Name: 2-((E)-3-((E)-5-((2,5,8,11-tetraoxatridecan-13-yl)oxy)-1,3,3-trimethylindolin-2-ylidene)prop-1-en-1-yl)-5-((14-azido-3,6,9,12-tetraoxatetradecyl)oxy)-1,3,3-trimethyl-3H-1l4-indole, chloride salt

InChi Key: QLPDOKULPAYFDR-CKTLXCRZSA-M

InChi Code: InChI=1S/C44H66N5O10.ClH/c1-43(2)37-33-35(58-31-29-56-27-25-54-22-21-52-18-17-50-7)11-13-39(37)48(5)41(43)9-8-10-42-44(3,4)38-34-36(12-14-40(38)49(42)6)59-32-30-57-28-26-55-24-23-53-20-19-51-16-15-46-47-45;/h8-14,33-34H,15-32H2,1-7H3;1H/p-1/b10-8+,41-9+;

SMILES Code: CC(C1=CC(OCCOCCOCCOCCOC)=CC=C1N/2C)(C)C2=C/C=C/C3=[N](C)C(C=CC(OCCOCCOCCOCCOCCN=[N+]=[N-])=C4)=C4C3(C)C.[Cl-]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, DMF, DCM, and water

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info: Excitation maximum = 555 nm Emission maximum = 570 nm

Product Data:
Biological target: QCM 00860 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
In vitro activity: TBD
In vivo activity: TBD

Preparing Stock Solutions

The following data is based on the product molecular weight 860.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol: TBD
In vitro protocol: TBD
In vivo protocol: TBD

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1: Chen X, Zhang X, Wang HY, Chen Z, Wu FG. Subcellular Fate of a Fluorescent Cholesterol-Poly(ethylene glycol) Conjugate: An Excellent Plasma Membrane Imaging Reagent. Langmuir. 2016 Oct 4;32(39):10126-10135. Epub 2016 Sep 21. PubMed PMID: 27597442.

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4: Ruan S, Wan J, Fu Y, Han K, Li X, Chen J, Zhang Q, Shen S, He Q, Gao H. PEGylated fluorescent carbon nanoparticles for noninvasive heart imaging. Bioconjug Chem. 2014 Jun 18;25(6):1061-8. doi: 10.1021/bc5001627. Epub 2014 May 22. PubMed PMID: 24852402.

5: Paira TK, Saha A, Banerjee S, Das T, Das P, Jana NR, Mandal TK. Fluorescent amphiphilic PEG-peptide-PEG triblock conjugate micelles for cell imaging. Macromol Biosci. 2014 Jul;14(7):929-35. doi: 10.1002/mabi.201400083. Epub 2014 Mar 31. PubMed PMID: 24687698.

6: Okuda T, Kobayashi Y, Yanamoto S, Okamoto H. PEG conjugation of a near-infrared fluorescent probe for noninvasive dual imaging of lung deposition and gene expression by pulmonary gene delivery. J Drug Target. 2012 Nov;20(9):801-12. doi: 10.3109/1061186X.2012.722639. Epub 2012 Sep 26. PubMed PMID: 23009266.