WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 563617
Description: JCP174-Et is a suicide substrate for serine proteases, irreversibly inactivating human leukocyte (HL) elastase, porcine pancreatic (PP) elastase, and chymotrypsin.
MedKoo Cat#: 563617
Chemical Formula: C11H9ClO3
Exact Mass: 224.024
Molecular Weight: 224.64
Elemental Analysis: C, 58.81; H, 4.04; Cl, 15.78; O, 21.37
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.
Synonym: JCP174-Et; JCP174 Et; JCP174Et;
IUPAC/Chemical Name: 4-Chloro-3-ethoxy-1H-2-benzopyran-1-one
InChi Key: OPIOPBBMUTWYPB-UHFFFAOYSA-N
InChi Code: InChI=1S/C11H9ClO3/c1-2-14-11-9(12)7-5-3-4-6-8(7)10(13)15-11/h3-6H,2H2,1H3
SMILES Code: O=C1C2=CC=CC=C2C(Cl)=C(OCC)O1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
The following data is based on the product molecular weight 224.64 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Harper JW, Powers JC. Reaction of serine proteases with substituted 3-alkoxy-4-chloroisocoumarins and 3-alkoxy-7-amino-4-chloroisocoumarins: new reactive mechanism-based inhibitors. Biochemistry. 1985 Dec 3;24(25):7200-13. PubMed PMID: 3910097.