WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 563615
CAS#: 136647-02-4 (HCl)
Description: UK-78282 HCl is a blocker of the KV1.3 and KV1.4 voltage-gated potassium channels.
MedKoo Cat#: 563615
Name: UK-78282 HCl
CAS#: 136647-02-4 (HCl)
Chemical Formula: C29H36ClNO2
Exact Mass: 465.2435
Molecular Weight: 466.06
Elemental Analysis: C, 74.74; H, 7.79; Cl, 7.61; N, 3.01; O, 6.87
Related CAS #: 191217-42-2 (free base) 136647-02-4 (HCl)
Synonym: UK-78282 Hydrochloride; UK 78282 Hydrochloride; UK78282 Hydrochloride; UK-78282 HCl; UK 78282 HCl; UK78282 HCl;
IUPAC/Chemical Name: 4-(Benzhydryloxymethyl)-1-[3-(4-methoxyphenyl)propyl]piperidine hydrochloride
InChi Key: ZZSQARULZYQMIG-UHFFFAOYSA-N
InChi Code: InChI=1S/C29H35NO2.ClH/c1-31-28-16-14-24(15-17-28)9-8-20-30-21-18-25(19-22-30)23-32-29(26-10-4-2-5-11-26)27-12-6-3-7-13-27;/h2-7,10-17,25,29H,8-9,18-23H2,1H3;1H
SMILES Code: COC1=CC=C(CCCN2CCC(COC(C3=CC=CC=C3)C4=CC=CC=C4)CC2)C=C1.[H]Cl
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
The following data is based on the product molecular weight 466.06 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Hanson DC, Nguyen A, Mather RJ, Rauer H, Koch K, Burgess LE, Rizzi JP, Donovan CB, Bruns MJ, Canniff PC, Cunningham AC, Verdries KA, Mena E, Kath JC, Gutman GA, Cahalan MD, Grissmer S, Chandy KG. UK-78,282, a novel piperidine compound that potently blocks the Kv1.3 voltage-gated potassium channel and inhibits human T cell activation. Br J Pharmacol. 1999 Apr;126(8):1707-16. PubMed PMID: 10372812; PubMed Central PMCID: PMC1565958.
