W-7 HCl
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MedKoo CAT#: 563607

CAS#: 61714-27-0

Description: W-7 HCl is a calmodulin antagonist, inhibiting Ca2+-calmodulin-dependent phosphodiesterase and myosin light chain kinase.


Chemical Structure

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W-7 HCl
CAS# 61714-27-0

Theoretical Analysis

MedKoo Cat#: 563607
Name: W-7 HCl
CAS#: 61714-27-0
Chemical Formula: C16H22Cl2N2O2S
Exact Mass:
Molecular Weight: 377.32
Elemental Analysis: C, 50.93; H, 5.88; Cl, 18.79; N, 7.42; O, 8.48; S, 8.50

Price and Availability

Size Price Availability Quantity
10.0mg USD 230.0 2 Weeks
50.0mg USD 360.0 2 Weeks
100.0mg USD 560.0 2 Weeks
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Synonym: W-7 hydrochloride; W-7 hydrochloride; W-7 hydrochloride; W-7 HCl; W 7 HCl; W7 HCl;

IUPAC/Chemical Name: N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide hydrochloride

InChi Key: OMMOSRLIFSCDBL-UHFFFAOYSA-N

InChi Code: InChI=1S/C16H21ClN2O2S.ClH/c17-15-9-5-8-14-13(15)7-6-10-16(14)22(20,21)19-12-4-2-1-3-11-18;/h5-10,19H,1-4,11-12,18H2;1H

SMILES Code: O=S(C1=C2C=CC=C(Cl)C2=CC=C1)(NCCCCCCN)=O.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

Preparing Stock Solutions

The following data is based on the product molecular weight 377.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Celotto AC, Capellini VK, Restini CB, Baldo CF, Bendhack LM, Evora PR. Extracellular alkalinization induces endothelium-derived nitric oxide dependent relaxation in rat thoracic aorta. Nitric Oxide. 2010 Dec 15;23(4):269-74. doi: 10.1016/j.niox.2010.07.008. Epub 2010 Aug 1. PubMed PMID: 20682356.

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4: Gonda K, Komatsu M, Numata O. Calmodulin and Ca2+/calmodulin-binding proteins are involved in Tetrahymena thermophila phagocytosis. Cell Struct Funct. 2000 Aug;25(4):243-51. PubMed PMID: 11129794.

5: Ichida S, Abe J, Yu-an Z, Sugihara K, Imoto K, Wada T, Sohma H. Calcium/calmodulin inhibits the binding of specific [125I]omega-conotoxin GVIA to chick brain membranes. Neurochem Res. 2000 Mar;25(3):335-40. PubMed PMID: 10761976.

6: Gonda K, Katoh M, Hanyu K, Watanabe Y, Numata O. Ca(2+)/calmodulin and p85 cooperatively regulate an initiation of cytokinesis in Tetrahymena. J Cell Sci. 1999 Nov;112 ( Pt 21):3619-26. PubMed PMID: 10523498.

7: Huang S, Maher VM, McCormick J. Involvement of intermediary metabolites in the pathway of extracellular Ca2+-induced mitogen-activated protein kinase activation in human fibroblasts. Cell Signal. 1999 Apr;11(4):263-74. PubMed PMID: 10372804.

8: Arai M, Sasaki Y, Nozawa R. Inhibition by the protein kinase inhibitor HA1077 of the activation of NADPH oxidase in human neutrophils. Biochem Pharmacol. 1993 Oct 19;46(8):1487-90. PubMed PMID: 8240400.

9: Yaney GC, Sharp GW. Calmodulin and insulin secretion: use of naphthalenesulfonamide compounds. Am J Physiol. 1990 Dec;259(6 Pt 1):E856-64. PubMed PMID: 1701970.

10: Lollar P, Parker CG. Subunit structure of thrombin-activated porcine factor VIII. Biochemistry. 1989 Jan 24;28(2):666-74. PubMed PMID: 2496750.

W-7 HCl

10.0mg / USD 230.0