Buthiobate

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 461610

CAS#: 51308-54-4

Description: Buthiobate is a fungicide which inhibits lanosterol 14 alpha-demethylation catalyzed by a cytochrome P-450.

Chemical Structure

img
Buthiobate
CAS# 51308-54-4
Instruction

Theoretical Analysis

MedKoo Cat#: 461610
Name: Buthiobate
CAS#: 51308-54-4
Chemical Formula: C21H28N2S2
Exact Mass: 372.17
Molecular Weight: 372.580
Elemental Analysis: C, 67.70; H, 7.58; N, 7.52; S, 17.21

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Buthiobate; Butiobate; Denmert; S 1358; S-1358; S1358;

IUPAC/Chemical Name: butyl (4-(tert-butyl)benzyl) (E)-pyridin-3-ylcarbonimidodithioate

InChi Key: ZZVVDIVWGXTDRQ-BSYVCWPDSA-N

InChi Code: InChI=1S/C21H28N2S2/c1-5-6-14-24-20(23-19-8-7-13-22-15-19)25-16-17-9-11-18(12-10-17)21(2,3)4/h7-13,15H,5-6,14,16H2,1-4H3/b23-20+

SMILES Code: CCCCS/C(SCC1=CC=C(C(C)(C)C)C=C1)=N\C2=CC=CN=C2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 372.58 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Yoshida Y, Aoyama Y. Effects of buthiobate, a fungicide, on cytochrome P-450 of rat liver microsomes. J Pharmacobiodyn. 1985 Jun;8(6):432-9. PubMed PMID: 4057038.

2: Aoyama Y, Yoshida Y, Hata S, Nishino T, Katsuki H. Buthiobate: a potent inhibitor for yeast cytochrome P-450 catalyzing 14 alpha-demethylation of lanosterol. Biochem Biophys Res Commun. 1983 Sep 15;115(2):642-7. PubMed PMID: 6414474.

3: Aoyama Y, Yoshida Y, Hata S, Nishino T, Katsuki H, Maitra US, Mohan VP, Sprinson DB. Altered cytochrome P-450 in a yeast mutant blocked in demethylating C-32 of lanosterol. J Biol Chem. 1983 Aug 10;258(15):9040-2. PubMed PMID: 6409899.

4: Aaberg AM, Larsen CE, Rasmussen BS, Hansen CM, Larsen JM. Basic life support knowledge, self-reported skills and fears in Danish high school students and effect of a single 45-min training session run by junior doctors; a prospective cohort study. Scand J Trauma Resusc Emerg Med. 2014 Apr 14;22:24. doi: 10.1186/1757-7241-22-24. PubMed PMID: 24731392; PubMed Central PMCID: PMC4022325.

5: Boogaard A, Griffioen M, Cohen LH. Regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase in human hepatoma cell line Hep G2. Effects of inhibitors of cholesterol synthesis on enzyme activity. Biochem J. 1987 Jan 15;241(2):345-51. PubMed PMID: 3036060; PubMed Central PMCID: PMC1147567.

6: Nakanishi S, Nishino T, Yabusaki Y, Fujisaki S, Katsuki H. Preparation of 14C-labeled and unlabeled sterol intermediates from yeast using metabolic inhibitors. J Biochem. 1984 Dec;96(6):1665-72. PubMed PMID: 6397465.

7: Hata S, Nishino T, Katsuki H, Aoyama Y, Yoshida Y. Two species of cytochrome P-450 involved in ergosterol biosynthesis of yeast. Biochem Biophys Res Commun. 1983 Oct 14;116(1):162-6. PubMed PMID: 6357195.