DBCO-PEG4-amine TFA
featured

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 572267

CAS#: 1840886-10-3 (free base)

Description: DBCO-PEG4-amine is a PEG derivative. PEG Linkers and derivatives may be useful in the development of antibody drug conjugates.

Chemical Structure

img
DBCO-PEG4-amine TFA
CAS# 1840886-10-3 (free base)
Instruction

Theoretical Analysis

MedKoo Cat#: 572267
Name: DBCO-PEG4-amine TFA
CAS#: 1840886-10-3 (free base)
Chemical Formula: C33H39F6N3O10
Exact Mass: 523.27
Molecular Weight: 751.680
Elemental Analysis: C, 52.73; H, 5.23; F, 15.16; N, 5.59; O, 21.28

Price and Availability

Size Price Availability Quantity
50mg USD 460
100mg USD 770 2 Weeks
500mg USD 2650 2 Weeks
Bulk inquiry

Related CAS #: 1840886-10-3 (free base)    

Synonym: DBCO-PEG4-amine; DBCO-PEG4-amine TFA salt;

IUPAC/Chemical Name: N-(14-Amino-3,6,9,12-tetraoxatetradec-1-yl)-11,12-didehydro-gamma-oxodibenz[b,f]azocine-5(6H)-butanamide: bis(trifluoracetic acid)

InChi Key: SJLFDWBNLVNFCC-UHFFFAOYSA-N

InChi Code: InChI=1S/C29H37N3O6.2C2HF3O2/c30-13-15-35-17-19-37-21-22-38-20-18-36-16-14-31-28(33)11-12-29(34)32-23-26-7-2-1-5-24(26)9-10-25-6-3-4-8-27(25)32;2*3-2(4,5)1(6)7/h1-8H,11-23,30H2,(H,31,33);2*(H,6,7)

SMILES Code: O=C(N1CC2=C(C#CC3=C1C=CC=C3)C=CC=C2)CCC(NCCOCCOCCOCCOCCN)=O.O=C(O)C(F)(F)F.O=C(O)C(F)(F)F

Appearance: liquid

Purity: >96% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 751.68 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Wang H, Tang L, Liu Y, Dobrucka IT, Dobrucki LW, Yin L, Cheng J. In Vivo Targeting of Metabolically Labeled Cancers with Ultra-Small Silica Nanoconjugates. Theranostics. 2016 Jun 16;6(9):1467-76. doi: 10.7150/thno.16003. eCollection 2016. PubMed PMID: 27375793; PubMed Central PMCID: PMC4924513.

2: Yoon HI, Yhee JY, Na JH, Lee S, Lee H, Kang SW, Chang H, Ryu JH, Lee S, Kwon IC, Cho YW, Kim K. Bioorthogonal Copper Free Click Chemistry for Labeling and Tracking of Chondrocytes In Vivo. Bioconjug Chem. 2016 Apr 20;27(4):927-36. doi: 10.1021/acs.bioconjchem.6b00010. Epub 2016 Mar 10. PubMed PMID: 26930274.

3: Zimmerman ES, Heibeck TH, Gill A, Li X, Murray CJ, Madlansacay MR, Tran C, Uter NT, Yin G, Rivers PJ, Yam AY, Wang WD, Steiner AR, Bajad SU, Penta K, Yang W, Hallam TJ, Thanos CD, Sato AK. Production of site-specific antibody-drug conjugates using optimized non-natural amino acids in a cell-free expression system. Bioconjug Chem. 2014 Feb 19;25(2):351-61. doi: 10.1021/bc400490z. Epub 2014 Jan 29. PubMed PMID: 24437342.