WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 461601
Description: S 0960 is a dimeric bile acid analogue that acts as a specific inhibitor of the apical sodium-dependent bile salt transporter (ASBT) in the ileum.
MedKoo Cat#: 461601
Name: S 0960
Chemical Formula: C48H79NO8
Exact Mass: 797.5806
Molecular Weight: 798.15
Elemental Analysis: C, 72.23; H, 9.98; N, 1.75; O, 16.04
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
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Synonym: S 0960; S-0960; S0960;
IUPAC/Chemical Name: (R)-4-((3S,5S,7R,8R,9S,10S,12S,13R,14S,17R)-7,12-dihydroxy-10,13-dimethyl-3-((R)-4-((3S,5R,7S,8R,9S,10S,12R,13R,14S,17R)-3,7,12-trihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanamido)hexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid
InChi Key: GCJPHGQNZBNLBM-NJWNICFVSA-N
InChi Code: InChI=1S/C48H79NO8/c1-25(31-9-11-34-44-36(24-40(54)47(31,34)5)46(4)18-16-30(50)20-28(46)22-38(44)52)7-13-41(55)49-29-15-17-45(3)27(19-29)21-37(51)43-33-12-10-32(26(2)8-14-42(56)57)48(33,6)39(53)23-35(43)45/h25-40,43-44,50-54H,7-24H2,1-6H3,(H,49,55)(H,56,57)/t25-,26-,27+,28-,29+,30+,31-,32-,33+,34+,35+,36+,37-,38+,39+,40-,43+,44+,45+,46+,47-,48-/m1/s1
SMILES Code: C[C@H](CCC(O)=O)[C@H]1CC[C@@]2([H])[C@]3([H])[C@H](O)C[C@]4([H])C[C@@H](NC(CC[C@@H](C)[C@H]5CC[C@@]6([H])[C@]7([H])[C@@H](O)C[C@@]8([H])C[C@@H](O)CC[C@]8(C)[C@@]7([H])C[C@@H](O)[C@]56C)=O)CC[C@]4(C)[C@@]3([H])C[C@H](O)[C@]12C
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
The following data is based on the product molecular weight 798.15 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Schlattjan JH, Fehsenfeld H, Greven J. Effect of the dimeric bile acid analogue S 0960, a specific inhibitor of the apical sodium-dependent bile salt transporter in the ileum, on the renal handling of taurocholate. Arzneimittelforschung. 2003;53(12):837-43. PubMed PMID: 14732964.