Butoctamide semisuccinate

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 598996

CAS#: 32838-28-1

Description: Butoctamide semisuccinate increases REM sleep in chronically prepared cats.


Chemical Structure

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Butoctamide semisuccinate
CAS# 32838-28-1

Theoretical Analysis

MedKoo Cat#: 598996
Name: Butoctamide semisuccinate
CAS#: 32838-28-1
Chemical Formula: C16H29NO5
Exact Mass: 315.20
Molecular Weight: 315.410
Elemental Analysis: C, 60.93; H, 9.27; N, 4.44; O, 25.36

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Butoctamide semisuccinate; M-2H; M 2H; M2H; Butoctamide hydrogen succinate;

IUPAC/Chemical Name: 4-((4-((2-ethylhexyl)amino)-4-oxobutan-2-yl)oxy)-4-oxobutanoic acid

InChi Key: CQONVBIGUJWUFE-UHFFFAOYSA-N

InChi Code: InChI=1S/C16H29NO5/c1-4-6-7-13(5-2)11-17-14(18)10-12(3)22-16(21)9-8-15(19)20/h12-13H,4-11H2,1-3H3,(H,17,18)(H,19,20)

SMILES Code: O=C(OC(C)CC(NCC(CC)CCCC)=O)CCC(O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 315.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Sasaki K, Furusawa S, Takayanagi G. [Butoctamide enhancement of the antitumor activity of 6-mercaptopurine on Ehrlich solid tumors in mice (author's transl)]. Nihon Yakurigaku Zasshi. 1981 Feb;77(2):131-9. Japanese. PubMed PMID: 6894582.

2: Mizuki Y, Suetsugi M, Hotta H, Ushijima I, Yamada M. Stimulatory effect of butoctamide hydrogen succinate on REM sleep in normal humans. Prog Neuropsychopharmacol Biol Psychiatry. 1995 May;19(3):385-401. PubMed PMID: 7624490.

3: Grubar JC, Gigli GL, Colognola RM, Ferri R, Musumeci SA, Bergonzi P. Sleep patterns of Down's syndrome children: effects of butoctamide hydrogen succinate (BAHS) administration. Psychopharmacology (Berl). 1986;90(1):119-22. PubMed PMID: 2945221.

4: Gigli GL, Grubar JC, Colognola RM, Amata MT, Pollicina C, Ferri R, Musumeci SA, Bergonzi P. Butoctamide hydrogen succinate and intensive learning sessions: effects on night sleep of Down's syndrome patients. Sleep. 1987 Dec;10(6):563-9. PubMed PMID: 2963363.

5: Hayashi Y, Otomo E, Okudaira N, Endo S. Drug-increased REM sleep in aged subjects: butoctamide hydrogen succinate (BAHS). Psychopharmacology (Berl). 1982;77(4):367-70. PubMed PMID: 6813899.

6: Okudaira N, Torii S, Endo S. The effect of butoctamide hydrogen succinate on nocturnal sleep: all-night polygraphical studies. Psychopharmacology (Berl). 1980;70(2):117-21. PubMed PMID: 6776569.

7: Tazaki T, Tada K, Nogami Y, Takemura N, Ishikawa K. Effects of butoctamide hydrogen succinate and nitrazepam on psychomotor function and EEG in healthy volunteers. Psychopharmacology (Berl). 1989;97(3):370-5. PubMed PMID: 2497487.

8: Gigli GL, Grubar JC, Bergonzi P, Maschio MC. Long-term administration of butoctamide hydrogen succinate on nocturnal sleep of mentally retarded subjects: a polygraphic study versus placebo. Psychopharmacology (Berl). 1995 Feb;117(4):438-42. PubMed PMID: 7604145.

9: Hayashi Y, Watanabe H, Okudaira N, Otomo E, Endo S. [The effects of butoctamide hydrogen succinate (BAHS) on the sleep of the aged people (author's transl)]. No To Shinkei. 1981 Dec;33(12):1243-50. Japanese. PubMed PMID: 7326156.

10: Kato S, Wakasa Y, Yanagita T. [Dependence study on butoctamide hydrogen succinate (M-2H) in rhesus monkeys]. Arukoru Kenkyuto Yakubutsu Ison. 1987 Dec;22(4):340-51. Japanese. PubMed PMID: 3449033.

11: Ohta T, Iwata T, Kayukawa Y, Okada T. Daily activity and persistent sleep-wake schedule disorders. Prog Neuropsychopharmacol Biol Psychiatry. 1992 Jul;16(4):529-37. PubMed PMID: 1641496.