BAPTA-AM
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MedKoo CAT#: 563565

CAS#: 126150-97-8

Description: BAPTA-AM is a selective, cell-permeable calcium chelator, blocking hKv1.5, hKV11.1 (hERG) and hKv1.3 channels.

Chemical Structure

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BAPTA-AM
CAS# 126150-97-8
Instruction

Theoretical Analysis

MedKoo Cat#: 563565
Name: BAPTA-AM
CAS#: 126150-97-8
Chemical Formula: C34H40N2O18
Exact Mass: 764.23
Molecular Weight: 764.690
Elemental Analysis: C, 53.40; H, 5.27; N, 3.66; O, 37.66

Price and Availability

Size Price Availability Quantity
5mg USD 220
10mg USD 350
25mg USD 550
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Synonym: BAPTA-AM; BAPTA AM; BAPTAAM; BAPTA/AM;

IUPAC/Chemical Name: Acetyloxymethyl 2-[N-[2-(acetyloxymethoxy)-2-oxoethyl]-2-[2-[2-[bis[2-(acetyloxymethoxy)-2-oxoethyl]amino]phenoxy]ethoxy]anilino]acetate

InChi Key: YJIYWYAMZFVECX-UHFFFAOYSA-N

InChi Code: InChI=1S/C34H40N2O18/c1-23(37)47-19-51-31(41)15-35(16-32(42)52-20-48-24(2)38)27-9-5-7-11-29(27)45-13-14-46-30-12-8-6-10-28(30)36(17-33(43)53-21-49-25(3)39)18-34(44)54-22-50-26(4)40/h5-12H,13-22H2,1-4H3

SMILES Code: O=C(OCOC(C)=O)CN(CC(OCOC(C)=O)=O)C1=CC=CC=C1OCCOC2=CC=CC=C2N(CC(OCOC(C)=O)=O)CC(OCOC(C)=O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 764.69 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Rcom-H'cheo-Gauthier A, Goodwin J, Pountney DL. Interactions between calcium and alpha-synuclein in neurodegeneration. Biomolecules. 2014 Aug 14;4(3):795-811. doi: 10.3390/biom4030795. Review. PubMed PMID: 25256602; PubMed Central PMCID: PMC4192672.

2: Shirakawa H. [Pathophysiological significance of the canonical transient receptor potential (TRPC) subfamily in astrocyte activation]. Yakugaku Zasshi. 2012;132(5):587-93. Review. Japanese. PubMed PMID: 22687694.

3: Brodsky VY, Zvezdina ND. Melatonin as the most effective organizer of the rhythm of protein synthesis in hepatocytes in vitro and in vivo. Cell Biol Int. 2010 Dec;34(12):1199-204. doi: 10.1042/CBI20100036. Review. PubMed PMID: 21067519.

4: Chen B, Nicol G, Cho WK. Role of calcium in volume-activated chloride currents in a mouse cholangiocyte cell line. J Membr Biol. 2007 Jan;215(1):1-13. Epub 2007 May 5. Review. PubMed PMID: 17483866.

5: Kito Y, Suzuki H. Electrophysiological properties of gastric pacemaker potentials. J Smooth Muscle Res. 2003 Oct;39(5):163-73. Review. PubMed PMID: 14695027.

6: Kuwabara M, Takahashi K, Inanami O. Induction of apoptosis through the activation of SAPK/JNK followed by the expression of death receptor Fas in X-irradiated cells. J Radiat Res. 2003 Sep;44(3):203-9. Review. PubMed PMID: 14646222.

7: Tymianski M, Spigelman I, Zhang L, Carlen PL, Tator CH, Charlton MP, Wallace MC. Mechanism of action and persistence of neuroprotection by cell-permeant Ca2+ chelators. J Cereb Blood Flow Metab. 1994 Nov;14(6):911-23. Review. PubMed PMID: 7929656.