BAPTA-AM
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MedKoo CAT#: 563565

CAS#: 126150-97-8

Description: BAPTA-AM is a selective, cell-permeable calcium chelator, blocking hKv1.5, hKV11.1 (hERG) and hKv1.3 channels.


Price and Availability

Size Price Shipping out time Quantity
5mg USD 220 2 Weeks
10mg USD 350 2 Weeks
25mg USD 550 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-10-29. Prices are subject to change without notice.

BAPTA-AM, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 563565
Name: BAPTA-AM
CAS#: 126150-97-8
Chemical Formula: C34H40N2O18
Exact Mass: 764.2276
Molecular Weight: 764.69
Elemental Analysis: C, 53.40; H, 5.27; N, 3.66; O, 37.66


Synonym: BAPTA-AM; BAPTA AM; BAPTAAM; BAPTA/AM;

IUPAC/Chemical Name: Acetyloxymethyl 2-[N-[2-(acetyloxymethoxy)-2-oxoethyl]-2-[2-[2-[bis[2-(acetyloxymethoxy)-2-oxoethyl]amino]phenoxy]ethoxy]anilino]acetate

InChi Key: YJIYWYAMZFVECX-UHFFFAOYSA-N

InChi Code: InChI=1S/C34H40N2O18/c1-23(37)47-19-51-31(41)15-35(16-32(42)52-20-48-24(2)38)27-9-5-7-11-29(27)45-13-14-46-30-12-8-6-10-28(30)36(17-33(43)53-21-49-25(3)39)18-34(44)54-22-50-26(4)40/h5-12H,13-22H2,1-4H3

SMILES Code: O=C(OCOC(C)=O)CN(CC(OCOC(C)=O)=O)C1=CC=CC=C1OCCOC2=CC=CC=C2N(CC(OCOC(C)=O)=O)CC(OCOC(C)=O)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.03.00


References

1: Rcom-H'cheo-Gauthier A, Goodwin J, Pountney DL. Interactions between calcium and alpha-synuclein in neurodegeneration. Biomolecules. 2014 Aug 14;4(3):795-811. doi: 10.3390/biom4030795. Review. PubMed PMID: 25256602; PubMed Central PMCID: PMC4192672.

2: Shirakawa H. [Pathophysiological significance of the canonical transient receptor potential (TRPC) subfamily in astrocyte activation]. Yakugaku Zasshi. 2012;132(5):587-93. Review. Japanese. PubMed PMID: 22687694.

3: Brodsky VY, Zvezdina ND. Melatonin as the most effective organizer of the rhythm of protein synthesis in hepatocytes in vitro and in vivo. Cell Biol Int. 2010 Dec;34(12):1199-204. doi: 10.1042/CBI20100036. Review. PubMed PMID: 21067519.

4: Chen B, Nicol G, Cho WK. Role of calcium in volume-activated chloride currents in a mouse cholangiocyte cell line. J Membr Biol. 2007 Jan;215(1):1-13. Epub 2007 May 5. Review. PubMed PMID: 17483866.

5: Kito Y, Suzuki H. Electrophysiological properties of gastric pacemaker potentials. J Smooth Muscle Res. 2003 Oct;39(5):163-73. Review. PubMed PMID: 14695027.

6: Kuwabara M, Takahashi K, Inanami O. Induction of apoptosis through the activation of SAPK/JNK followed by the expression of death receptor Fas in X-irradiated cells. J Radiat Res. 2003 Sep;44(3):203-9. Review. PubMed PMID: 14646222.

7: Tymianski M, Spigelman I, Zhang L, Carlen PL, Tator CH, Charlton MP, Wallace MC. Mechanism of action and persistence of neuroprotection by cell-permeant Ca2+ chelators. J Cereb Blood Flow Metab. 1994 Nov;14(6):911-23. Review. PubMed PMID: 7929656.